Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 1/20 | 0.56 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.50 |
| ▸ | IDO1 | P14902 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.44 |
| ▸ | PTPRC | P08575 | 1/20 | 0.44 |
| ▸ | PTPRG | P23470 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | CXCL8 | P10145 | 2/20 | 0.42 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.42 |
| ▸ | UGT1A9 | O60656 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3393837 | 0.85 | PNMT (0.59) | PNMTTAAR1IDO1TSHRAKR1B1 | |
| SCHEMBL29760897 | 0.85 | PNMT (0.59) | PNMTTAAR1IDO1TSHRAKR1B1 | |
| SCHEMBL6194277 | 0.84 | PNMT (0.58) | PNMTTAAR1IDO1TSHRAKR1B1 | |
| SCHEMBL286906 | 0.84 | CTBP2 (0.56) | PNMTIDO1ALDH1A1MEN1KMT2A | |
| SCHEMBL29810302 | 0.84 | CTBP2 (0.56) | PNMTIDO1ALDH1A1MEN1KMT2A | |
| SCHEMBL10423282 | 0.83 | AKR1B1 (0.53) | TSHRAKR1B1ALDH1A1MEN1KMT2A | |
| SCHEMBL2547244 | 0.83 | AKR1B1 (0.63) | PNMTTAAR1IDO1TSHRAKR1B1 | |
| SCHEMBL6961042 | 0.83 | PNMT (0.56) | PNMTTAAR1IDO1TSHRAKR1B1 | |
| SCHEMBL24977211 | 0.82 | ANO1 (0.41) | PNMTTAAR1ALDH1A1MEN1KMT2A | |
| SCHEMBL11349111 | 0.82 | TAAR1 (0.55) | PNMTTAAR1IDO1TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108707114-B | Acetamide compound and preparation method and application thereof | 上海泰禾国际贸易有限公司 | 2021-07-23 | — | — | CN | disclosed |
| CN-108707114-A | A kind of acetamides and its preparation method and application | 上海泰禾国际贸易有限公司 | 2018-10-26 | — | — | CN | disclosed |
| US-10071994-B2 | N-sulfonyl homoserine lactone derivatives, preparation method and use thereof | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2018-09-11 | — | — | US | disclosed |
| US-20180179193-A1 | N-Sulfonyl Homoserine Lactone Derivatives, Preparation Method and Use Thereof | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2018-06-28 | — | — | US | disclosed |
| EP-3150594-A1 | N-SULFONYL HOMOSERINE LACTONE DERIVATIVES, PREPARATION METHOD THEREFOR AND USE | Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China (CN) | 2017-04-05 | — | — | EP | disclosed |
| US-9447134-B2 | Compounds and methods for treating mammalian gastrointestinal microbial infections | BRANDEIS UNIVERSITY (US) | 2016-09-20 | — | — | US | disclosed |
| US-9447134-B2 | Compounds and methods for treating mammalian gastrointestinal microbial infections | BRANDEIS UNIVERSITY (US) | 2016-09-20 | — | — | US | disclosed |
| US-9447134-B2 | Compounds and methods for treating mammalian gastrointestinal microbial infections | BRANDEIS UNIVERSITY (US) | 2016-09-20 | — | — | US | disclosed |
| US-20150210727-A1 | COMPOUNDS AND METHODS FOR TREATING MAMMALIAN GASTROINTESTINAL MICROBIAL INFECTIONS | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2015-07-30 | — | — | US | disclosed |
| US-20150210727-A1 | COMPOUNDS AND METHODS FOR TREATING MAMMALIAN GASTROINTESTINAL MICROBIAL INFECTIONS | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2015-07-30 | — | — | US | disclosed |
| EP-0361791-A2 | Azacyclic derivatives useful as medicaments | Smithkline Beecham Farmaceutici S.p.A. (IT) | 1990-04-04 | — | — | EP | disclosed |
| US-4876269-A | ANALGESICS, DIURETICS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1989-10-24 | — | — | US | disclosed |
| EP-0330360-A1 | 1,2,3,4-Tetrahydroisoquinolines, processes for their preparation, and their use as kappa-receptor agonists | SmithKline Beecham Farmaceutici S.p.A. (IT) | 1989-08-30 | — | — | EP | disclosed |
| EP-0325406-A2 | Diamine compounds | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1989-07-26 | — | — | EP | disclosed |
| EP-0260555-A1 | Benzo-fused cycloalkane and oxa- and thia-, cycloalkane trans-1,2-diamine derivatives | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1988-03-23 | — | — | EP | disclosed |
| EP-0116639-A4 | ACYL GUANIDINES. | RORER INTERNAT OVERSEAS INC (US) | 1985-09-25 | — | — | EP | disclosed |
| US-4502883-A | CONTAINING CHLORINE | IDEMITSU KOSAN COMPANY LIMITED (JP) | 1985-03-05 | — | — | US | disclosed |
| EP-0116639-A1 | ACYL GUANIDINES | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1984-08-29 | — | — | EP | disclosed |
| US-4455164-A | HALOGENATED DERIVATIVES | IDEMITSU KOSAN COMPANY LIMITED (JP) | 1984-06-19 | — | — | US | disclosed |
| WO-1984000875-A1 | ACYL GUANIDINES | RORER INT OVERSEAS (US) | 1984-03-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150210727-A1 | COMPOUNDS AND METHODS FOR TREATING MAMMALIAN GASTROINTESTINAL MICROBIAL INFECTIONS | IMPDH1, IMPDH2, IMPA1 | PNMT 426/4885TAAR1 3357/4885IDO1 7/4885 |
| US-20180179193-A1 | N-Sulfonyl Homoserine Lactone Derivatives, Preparation Method and Use Thereof | LSS, SOS1, STS | PNMT 1396/4885TAAR1 4030/4885IDO1 2766/4885 |
| US-10071994-B2 | N-sulfonyl homoserine lactone derivatives, preparation method and use thereof | LSS, SOS1, STS | PNMT 1562/4885TAAR1 4139/4885IDO1 3010/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.