Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | IKBKB | O14920 | 2/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | GRK6 | P43250 | 1/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.35 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.35 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.35 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13575479 | 0.91 | DGAT1 (0.48) | DGAT1ROCK2IKBKBHDAC1HDAC6 | |
| SCHEMBL17774979 | 0.86 | DGAT1 (0.44) | DGAT1ROCK2IKBKBHDAC1HDAC6 | |
| SCHEMBL2323641 | 0.83 | DGAT1 (0.54) | DGAT1ROCK2CES2CES1PARP10 | |
| SCHEMBL811340 | 0.83 | DGAT1 (0.58) | DGAT1ROCK2KEAP1CES2CES1 | |
| SCHEMBL30222084 | 0.82 | KEAP1 (0.50) | HDAC1HDAC6KEAP1ALDH1A1MEN1 | |
| SCHEMBL604580 | 0.82 | KEAP1 (0.50) | HDAC1HDAC6KEAP1ALDH1A1MEN1 | |
| Hydrochloric Acid SCHEMBL29810612 | 0.81 | DGAT1 (0.52) | DGAT1ROCK2KEAP1CES2CES1 | |
| SCHEMBL2858381 | 0.81 | DGAT1 (0.40) | DGAT1IKBKBHDAC1HDAC6GRK6 | |
| SCHEMBL20644035 | 0.81 | DGAT1 (0.44) | DGAT1ROCK2IKBKBHDAC1HDAC6 | |
| SCHEMBL9878198 | 0.81 | CA12 (0.46) | DGAT1KEAP1ALDH1A1MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170348258-A1 | 3-Amino Benzamide Derivative Serving As B-Lactam Auxiliary Antibiotic, Preparation Method and Use Thereof | THE HONG KONG POLYTECHNIC UNIVERSITY (CN) | 2017-12-07 | — | — | US | claimed |
| CN-114585616-B | Amide derivatives and their use in medicine | 广东东阳光药业股份有限公司 | 2024-01-16 | — | — | CN | disclosed |
| CN-114585616-A | Amide derivatives and their use in medicine | 广东东阳光药业有限公司 | 2022-06-03 | — | — | CN | disclosed |
| WO-2021031071-A1 | AMIDE DERIVATIVE AND USE THEREOF IN MEDICINE | 广东东阳光药业有限公司 | 2021-02-25 | — | — | WO | disclosed |
| US-20170348258-A1 | 3-Amino Benzamide Derivative Serving As B-Lactam Auxiliary Antibiotic, Preparation Method and Use Thereof | THE HONG KONG POLYTECHNIC UNIVERSITY (CN) | 2017-12-07 | — | — | US | disclosed |
| US-20170348258-A1 | 3-Amino Benzamide Derivative Serving As B-Lactam Auxiliary Antibiotic, Preparation Method and Use Thereof | THE HONG KONG POLYTECHNIC UNIVERSITY (CN) | 2017-12-07 | — | — | US | disclosed |
| CN-105461585-A | 3-aminobenzamide derivative as beta-lactam auxiliary antibiotic, preparation method and application | UNIV HONG KONG POLYTECHNIC | 2016-04-06 | — | — | CN | disclosed |
| EP-2061756-B1 | 2-AMINOCARBONYLPHENYLAMINO-2-PHENILACETAMIDES AS FACTOR VIIA INHIBITORS USEFUL AS ANTICOAGULANTS | BRISTOL MYERS SQUIBB CO (US) | 2013-09-25 | — | — | EP | disclosed |
| US-8222453-B2 | Benzamide factor VIIa inhibitors useful as anticoagulants | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-07-17 | — | — | US | disclosed |
| US-20100227894-A1 | BENZAMIDE FACTOR VIIA INHIBITORS USEFUL AS ANTICOAGULANTS | BRISTOL-MYERS SQUIBB COMPANY | 2010-09-09 | — | — | US | disclosed |
| WO-2009075960-A1 | CCR5 ANTAGONISTS AS THERAPEUTIC AGENTS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-18 | — | — | WO | disclosed |
| WO-2009058923-A1 | CCR5 ANTAGONISTS AS THERAPEUTIC AGENTS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-05-07 | — | — | WO | disclosed |
| WO-2009058919-A1 | CCR5 ANTAGONISTS AS THERAPEUTIC AGENTS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-05-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170348258-A1 | 3-Amino Benzamide Derivative Serving As B-Lactam Auxiliary Antibiotic, Preparation Method and Use Thereof | BCAT2, SBDS, BCAT1 | DGAT1 3946/4885ROCK2 4845/4885IKBKB 265/4885 |
| US-20100227894-A1 | BENZAMIDE FACTOR VIIA INHIBITORS USEFUL AS ANTICOAGULANTS | F7, F9, F8 | DGAT1 3618/4885ROCK2 1983/4885IKBKB 218/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.