SCHEMBL30869706

SCHEMBL30869706

CN1C[C@H]2C[C@@H]1CN2CCN1c2ccc(-c3cncc4[nH]ncc34)cc2Sc2cc(-c3cncc4[nH]ncc34)ccc21

nearest known ligand 0.38

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
CHRNA7 P36544 5/20 0.38
KCNH2 Q12809 2/20 0.37
BRAF P15056 14/20 0.35
ABL1 P00519 2/20 0.35
EGFR P00533 1/20 0.33
RAF1 P04049 1/20 0.33
LCK P06239 1/20 0.33
YES1 P07947 1/20 0.33
RET P07949 1/20 0.33
EPHA1 P21709 1/20 0.33
TEK Q02763 1/20 0.33
MAPK14 Q16539 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30869697 0.89 BRAF (0.42) CHRNA7KCNH2BRAFABL1EGFR
SCHEMBL30869727 0.86 BRAF (0.39) BRAFABL1
SCHEMBL30869668 0.83 NUDT1 (0.39) CHRNA7KCNH2MAPK14
SCHEMBL30869658 0.78 CHRNA7 (0.47) CHRNA7KCNH2ABL1
SCHEMBL30869548 0.77 BRAF (0.42) CHRNA7KCNH2BRAFABL1EGFR
SCHEMBL30869669 0.75 ABL1 (0.36) BRAFABL1RET
SCHEMBL30869614 0.75 RXRA (0.34)
SCHEMBL30869510 0.74 BRAF (0.41) KCNH2BRAFABL1
SCHEMBL30869646 0.70 CHRNA7 (0.56) CHRNA7KCNH2LCKRET
SCHEMBL30869672 0.70 CHRNA7 (0.56) CHRNA7KCNH2LCKRET

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4583868-A2 DYNAMIN ACTIVATORS Walden Biosciences, Inc. (US) 2025-07-16 EP disclosed
WO-2024054661-A2 DYNAMIN ACTIVATORS WALDEN BIOSCIENCES (US) 2024-03-14 WO disclosed