SCHEMBL30869729

SCHEMBL30869729

O=S1(=O)c2cc(-c3cccc4[nH]ncc34)ccc2N(CCN2CCOCC2)c2ccc(-c3cccc4[nH]ncc34)cc21

nearest known ligand 0.48

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
PIK3CG P48736 1/20 0.48
PIK3CA P42336 15/20 0.42
PIK3CD O00329 1/20 0.41
PIK3R1 P27986 1/20 0.41
CREBBP Q92793 1/20 0.41
WNT1 P04628 1/20 0.41
DYRK1A Q13627 1/20 0.41
MTOR P42345 1/20 0.40
METAP2 P50579 1/20 0.39
ATR Q13535 1/20 0.39
PIK3CB P42338 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30869756 0.84 PIK3CG (0.49) PIK3CGPIK3CAPIK3CDPIK3R1CREBBP
SCHEMBL30869711 0.78 PRKCQ (0.45) PIK3CGPIK3CAPIK3CDMTORPIK3CB
SCHEMBL30869587 0.76 PIK3CG (0.41) PIK3CGPIK3CAPIK3CDPIK3R1WNT1
SCHEMBL30869717 0.75 PIK3CG (0.41) PIK3CGPIK3CAPIK3CDPIK3R1CREBBP
SCHEMBL30869877 0.71 PIK3CD (0.48) PIK3CAPIK3CDPIK3CB
SCHEMBL30869456 0.70 EGFR (0.53) PIK3CADYRK1A
SCHEMBL30869577 0.70 AR (0.47) WNT1DYRK1A
SCHEMBL1310548 0.68 ATR (0.58) PIK3CGPIK3CAPIK3CDMTORMETAP2
SCHEMBL30869650 0.68 PIK3CD (0.47) PIK3CAPIK3CDPIK3CB
SCHEMBL32682887 0.68 EGFR (0.52) PIK3CADYRK1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4583868-A2 DYNAMIN ACTIVATORS Walden Biosciences, Inc. (US) 2025-07-16 EP disclosed
WO-2024054661-A2 DYNAMIN ACTIVATORS WALDEN BIOSCIENCES (US) 2024-03-14 WO disclosed