SCHEMBL30869650

SCHEMBL30869650

c1cc(-c2ccc3c(c2)Sc2cc(-c4ccnc5[nH]ncc45)ccc2N3CCN2CCOCC2)c2cn[nH]c2n1

nearest known ligand 0.47

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
PIK3CD O00329 1/20 0.47
PIK3CA P42336 1/20 0.47
PIK3CB P42338 1/20 0.47
PRKCQ Q04759 4/20 0.46
KDM1A O60341 9/20 0.45
TLR8 Q9NR97 3/20 0.43
TLR7 Q9NYK1 3/20 0.43
NUDT1 P36639 1/20 0.42
NEK1 Q96PY6 1/20 0.40
TGFBR1 P36897 1/20 0.40
TLR9 Q9NR96 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30869711 0.93 PRKCQ (0.45) PIK3CDPIK3CAPIK3CBPRKCQKDM1A
SCHEMBL30869877 0.87 PIK3CD (0.48) PIK3CDPIK3CAPIK3CBPRKCQTLR8
SCHEMBL30869756 0.83 PIK3CG (0.49) PIK3CDPIK3CAPIK3CBKDM1A
SCHEMBL30869758 0.81 KDM1A (0.47) PIK3CAKDM1A
SCHEMBL30869668 0.79 NUDT1 (0.39) PRKCQTLR8TLR7NUDT1TLR9
SCHEMBL32682887 0.79 EGFR (0.52) PIK3CAPRKCQKDM1A
SCHEMBL30869495 0.77 NUDT1 (0.39) PRKCQTLR8TLR7NUDT1TLR9
SCHEMBL30869663 0.75 CD274 (0.39) KDM1A
SCHEMBL30869723 0.74 PRKCQ (0.42) PIK3CDPIK3CAPIK3CBPRKCQTLR8
SCHEMBL32682882 0.71 KDM1A (0.47) KDM1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4583868-A2 DYNAMIN ACTIVATORS Walden Biosciences, Inc. (US) 2025-07-16 EP disclosed
WO-2024054661-A2 DYNAMIN ACTIVATORS WALDEN BIOSCIENCES (US) 2024-03-14 WO disclosed