SCHEMBL30869877

SCHEMBL30869877

c1cc(-c2ccc3c(c2)Oc2cc(-c4ccnc5[nH]ncc45)ccc2N3CCN2CCOCC2)c2cn[nH]c2n1

nearest known ligand 0.48

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
PIK3CD O00329 1/20 0.48
PIK3CA P42336 1/20 0.48
PIK3CB P42338 1/20 0.48
PRKCQ Q04759 5/20 0.46
TLR8 Q9NR97 5/20 0.44
TLR7 Q9NYK1 5/20 0.44
NUDT1 P36639 2/20 0.42
NEK1 Q96PY6 1/20 0.41
TGFBR1 P36897 2/20 0.40
TLR9 Q9NR96 3/20 0.40
TNIK Q9UKE5 1/20 0.39
BRD4 O60885 1/20 0.39
ACVR1 Q04771 1/20 0.38
CSNK1D P48730 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30869650 0.87 PIK3CD (0.47) PIK3CDPIK3CAPIK3CBPRKCQTLR8
SCHEMBL30869723 0.87 PRKCQ (0.42) PIK3CDPIK3CAPIK3CBPRKCQTLR8
SCHEMBL30869711 0.83 PRKCQ (0.45) PIK3CDPIK3CAPIK3CBPRKCQTLR8
SCHEMBL30869717 0.81 PIK3CG (0.41) PIK3CDPIK3CATGFBR1BRD4CSNK1D
SCHEMBL30869745 0.81 PDE10A (0.45) PIK3CATNIKCSNK1D
SCHEMBL30869618 0.79 BRAF (0.39) PRKCQTLR8TLR7NUDT1TLR9
SCHEMBL30869456 0.78 EGFR (0.53) PIK3CAPRKCQACVR1CSNK1D
SCHEMBL30869734 0.73 EGFR (0.55) PIK3CAPRKCQACVR1CSNK1D
SCHEMBL30869573 0.73 EGFR (0.53) PIK3CAPRKCQACVR1CSNK1D
SCHEMBL30869570 0.73 EGFR (0.52) PIK3CACSNK1D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4583868-A2 DYNAMIN ACTIVATORS Walden Biosciences, Inc. (US) 2025-07-16 EP disclosed
WO-2024054661-A2 DYNAMIN ACTIVATORS WALDEN BIOSCIENCES (US) 2024-03-14 WO disclosed