SCHEMBL30869723

SCHEMBL30869723

c1cc(-c2ccc3c(c2)Oc2cc(-c4ccnc5[nH]ncc45)ccc2N3CCN2CC3(COC3)C2)c2cn[nH]c2n1

nearest known ligand 0.42

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
PRKCQ Q04759 7/20 0.42
NUDT1 P36639 1/20 0.40
TLR8 Q9NR97 6/20 0.39
TLR7 Q9NYK1 6/20 0.39
TLR9 Q9NR96 4/20 0.39
PIK3CD O00329 1/20 0.38
PIK3CA P42336 1/20 0.38
PIK3CB P42338 1/20 0.38
TNIK Q9UKE5 1/20 0.37
BRD4 O60885 1/20 0.36
CD38 P28907 1/20 0.36
CSNK1D P48730 1/20 0.35
MAPK11 Q15759 1/20 0.35
MAPK14 Q16539 1/20 0.35
JAK2 O60674 1/20 0.35
ROCK2 O75116 1/20 0.35
PRKCD Q05655 1/20 0.35
ROCK1 Q13464 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30869877 0.87 PIK3CD (0.48) PRKCQNUDT1TLR8TLR7TLR9
SCHEMBL30869853 0.82 ABL1 (0.36) PIK3CACD38
SCHEMBL30869841 0.82 PDE10A (0.37) PIK3CATNIKCD38CSNK1DJAK2
SCHEMBL30869445 0.80 GRIA1 (0.43) PRKCQCD38CSNK1DJAK2ROCK2
SCHEMBL30869686 0.77 ATR (0.34) BRD4
SCHEMBL30869618 0.76 BRAF (0.39) PRKCQNUDT1TLR8TLR7TLR9
SCHEMBL30869796 0.74 GRIA1 (0.42) PRKCQCSNK1DJAK2ROCK2ROCK1
SCHEMBL30869650 0.74 PIK3CD (0.47) PRKCQNUDT1TLR8TLR7TLR9
SCHEMBL30869426 0.74 GRIA1 (0.42) PRKCQCD38CSNK1DJAK2ROCK2
SCHEMBL30869822 0.74 GRIA1 (0.41) PRKCQCSNK1DJAK2ROCK2ROCK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4583868-A2 DYNAMIN ACTIVATORS Walden Biosciences, Inc. (US) 2025-07-16 EP disclosed
WO-2024054661-A2 DYNAMIN ACTIVATORS WALDEN BIOSCIENCES (US) 2024-03-14 WO disclosed