Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
| ▸ | BID | P55957 | 4/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.36 |
| ▸ | BCL2L1 | Q07817 | 3/20 | 0.36 |
| ▸ | BAK1 | Q16611 | 3/20 | 0.36 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.36 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | EP300 | Q09472 | 1/20 | 0.36 |
| ▸ | KAT2A | Q92830 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2778138 | 0.95 | BID (0.38) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL28453652 | 0.94 | BID (0.40) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL28457170 | 0.94 | BID (0.40) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL3483399 | 0.90 | KDM4E (0.38) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL8654059 | 0.83 | HMGB1 (0.42) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL6565772 | 0.83 | BID (0.49) | MEN1KMT2AKDM4EMAPTHSD17B10 | |
| SCHEMBL6567329 | 0.82 | HMGB1 (0.41) | KDM4EMAPTHSD17B10HMGB1BID | |
| SCHEMBL8654089 | 0.82 | HMGB1 (0.41) | KDM4EMAPTHSD17B10HMGB1BID | |
| SCHEMBL6566933 | 0.82 | BID (0.55) | MEN1KMT2AKDM4EMAPTHSD17B10 | |
| SCHEMBL8654374 | 0.82 | HMGB1 (0.41) | KDM4EMAPTHSD17B10HMGB1BID |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105899503-B | Selective GRP94 inhibitors and uses thereof | 纪念斯隆-凯特琳癌症中心 | 2020-08-18 | — | — | CN | disclosed |
| US-20120122760-A1 | NOVEL LIPIDS FOR TRANSFECTION OF NUCLEIC ACIDS | THOMPSON, PATRICK R. | 2012-05-17 | — | — | US | disclosed |
| US-8092661-B2 | Electropolymerisable monomers, soluble in an aqueous solution and comprising a metalloporphyrin | BIOMERIEUX (FR) | 2012-01-10 | — | — | US | disclosed |
| US-8034977-B2 | Lipids for transfection of nucleic acids | MOLECULAR TRANSFER, INC. (US) | 2011-10-11 | — | — | US | disclosed |
| US-7687070-B2 | Reagents for intracellular delivery of macromolecules | Life Technologies Corporation (US) | 2010-03-30 | — | — | US | disclosed |
| US-20090314660-A1 | Novel Electropolymerisable Monomers, Soluble in an Aqueous Solution and Comprising a Metalloporphyrin | BIOMERIEUX (FR) | 2009-12-24 | — | — | US | disclosed |
| US-7585970-B2 | Method of polynucleotide synthesis using modified support | AGILENT TECHNOLOGIES, INC. (US) | 2009-09-08 | — | — | US | disclosed |
| US-20090215067-A1 | NOVEL LIPIDS FOR TRANSFECTION OF NUCLEIC ACIDS | MOLECULAR TRANSFER, INC. (US) | 2009-08-27 | — | — | US | disclosed |
| US-7531693-B2 | Lipids for transfection of nucleic acids | MOLECULAR TRANSFER, INC. (US) | 2009-05-12 | — | — | US | disclosed |
| US-7417139-B2 | Method for polynucleotide synthesis | AGILENT TECHNOLOGIES, INC. (US) | 2008-08-26 | — | — | US | disclosed |
| EP-1628647-A4 | NOVEL LIPIDS FOR TRANSFECTION OF NUCLEIC ACIDS | MOLECULAR TRANSFER INC (US) | 2007-10-24 | — | — | EP | disclosed |
| EP-1628647-A2 | NOVEL LIPIDS FOR TRANSFECTION OF NUCLEIC ACIDS | Molecular Transfer, Inc. (US) | 2006-03-01 | — | — | EP | disclosed |
| US-6989434-B1 | Reagents for intracellular delivery of macromolecules | INVITROGEN CORPORATION (US) | 2006-01-24 | — | — | US | disclosed |
| US-20050260757-A1 | Novel reagents for intracellular delivery of macromolecules | INVITROGEN COROPORATION (US) | 2005-11-24 | — | — | US | disclosed |
| US-20050048496-A1 | Method of polynucleotide synthesis using modified support | AGILENT TECHNOLOGIES, INC. | 2005-03-03 | — | — | US | disclosed |
| US-20050048601-A1 | Method for polynucleotide synthesis | REGENTS OF THE UNIVERSITY OF COLORADO, THE | 2005-03-03 | — | — | US | disclosed |
| EP-1510522-A1 | Method of polynucleotide synthesis using modified support | Agilent Technologies Inc (US) | 2005-03-02 | — | — | EP | disclosed |
| US-20050014962-A1 | Novel lipids for transfection of nucleic acids | THOMPSON AND PATRICIA A THOMPSON AS TRUSTEES OF THE THOMPSON FAMILY TRUST DATED AUGUST 27 2002, JOHN D. | 2005-01-20 | — | — | US | disclosed |
| WO-2004105697-A2 | NOVEL LIPIDS FOR TRANSFECTION OF NUCLEIC ACIDS | MOLECULAR TRANSFER, INC. (US) | 2004-12-09 | — | — | WO | disclosed |
| US-6075012-A | TRANSFECTION | LIFE TECHNOLOGIES, INC. (US) | 2000-06-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050048496-A1 | Method of polynucleotide synthesis using modified support | POLN, POLRMT, POLM | MEN1 3171/4885KMT2A 2545/4885KDM4E 3869/4885 |
| US-20050260757-A1 | Novel reagents for intracellular delivery of macromolecules | NPC1L1, CETP, LIPA | MEN1 1702/4885KMT2A 3537/4885KDM4E 3854/4885 |
| US-20050014962-A1 | Novel lipids for transfection of nucleic acids | ABHD16A, MBOAT7, NPC1L1 | MEN1 2648/4885KMT2A 3361/4885KDM4E 4549/4885 |
| US-20050048601-A1 | Method for polynucleotide synthesis | POLN, RNGTT, NSUN2 | MEN1 3402/4885KMT2A 1288/4885KDM4E 2927/4885 |
| US-20090215067-A1 | NOVEL LIPIDS FOR TRANSFECTION OF NUCLEIC ACIDS | ABHD16A, MBOAT7, NPC1L1 | MEN1 2648/4885KMT2A 3361/4885KDM4E 4549/4885 |
| US-20090314660-A1 | Novel Electropolymerisable Monomers, Soluble in an Aqueous Solution and Comprising a Metalloporphyrin | EPS15, PPOX, ACR | MEN1 536/4885KMT2A 4151/4885KDM4E 3844/4885 |
| US-20120122760-A1 | NOVEL LIPIDS FOR TRANSFECTION OF NUCLEIC ACIDS | ABHD16A, MBOAT7, NPC1L1 | MEN1 2648/4885KMT2A 3361/4885KDM4E 4549/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.