Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 1/20 | 0.44 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 5/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL137184 | 0.80 | ALOX15 (0.61) | HCAR2KDM4EALDH1A1SMN1; SMN2ALOX15 | |
| SCHEMBL17465991 | 0.79 | NOS3 (0.50) | HCAR3HCAR2KDM4EALDH1A1ALOX15 | |
| Hydrochloric Acid SCHEMBL28437239 | 0.78 | ALOX15 (0.58) | HCAR2KDM4EALDH1A1SMN1; SMN2ALOX15 | |
| SCHEMBL31336152 | 0.75 | ALDH1A1 (0.47) | HCAR2KDM4EALDH1A1SMN1; SMN2ALOX15 | |
| SCHEMBL29084219 | 0.75 | ALOX15 (0.50) | HCAR2KDM4EALDH1A1SMN1; SMN2ALOX15 | |
| SCHEMBL1424923 | 0.75 | ALDH1A1 (0.47) | HCAR2KDM4EALDH1A1SMN1; SMN2ALOX15 | |
| SCHEMBL5918457 | 0.74 | KDM4E (0.50) | HCAR2KDM4EALDH1A1SMN1; SMN2ALOX15 | |
| SCHEMBL31500516 | 0.74 | KDM4E (0.50) | HCAR2KDM4EALDH1A1SMN1; SMN2ALOX15 | |
| SCHEMBL3087311 | 0.74 | HCAR3 (0.41) | HCAR3HCAR2KDM4EALDH1A1ALOX15 | |
| SCHEMBL1425370 | 0.73 | ALDH1A1 (0.46) | HCAR2KDM4EALDH1A1SMN1; SMN2ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100050-A1 | PYRIDINE-2-YL-CARBOXYLIC ACID AMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-09-10 | — | — | WO | disclosed |
| US-20100227887-A1 | PYRIDINE-2-YL CARBOXYLIC ACID AMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-09-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100227887-A1 | PYRIDINE-2-YL CARBOXYLIC ACID AMIDES | GRM2, GRM1, GRM3 | HCAR3 30/4885HCAR2 22/4885KDM4E 1168/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.