Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B known ✓ | P49841 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 3/20 | 0.45 |
| ▸ | CA1 | P00915 | 2/20 | 0.45 |
| ▸ | P4HB | P07237 | 1/20 | 0.45 |
| ▸ | SNCA | P37840 | 1/20 | 0.44 |
| ▸ | FBP1 | P09467 | 4/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA3 | P07451 | 1/20 | 0.43 |
| ▸ | CA6 | P23280 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzene SCHEMBL28598325 | 0.89 | ALDH1A1 (0.52) | ALDH1A1L3MBTL1LMNAMAPTKMT2A | |
| SCHEMBL127502 | 0.89 | ALDH1A1 (0.58) | ALDH1A1L3MBTL1LMNAMAPTKMT2A | |
| Styrene SCHEMBL11503937 | 0.85 | ALDH1A1 (0.61) | ALDH1A1L3MBTL1LMNAMAPTKMT2A | |
| SCHEMBL10243387 | 0.83 | MMP3 (0.52) | ALDH1A1LMNAKMT2AKDM4EHDAC2 | |
| SCHEMBL8351562 | 0.83 | MMP3 (0.52) | ALDH1A1LMNAKMT2AKDM4EHDAC2 | |
| Styrene SCHEMBL27589633 | 0.83 | ALDH1A1 (0.64) | ALDH1A1L3MBTL1LMNAMAPTKMT2A | |
| SCHEMBL12567409 | 0.83 | ALDH1A1 (0.50) | ALDH1A1L3MBTL1LMNAMAPTKMT2A | |
| Bicarbonate SCHEMBL11600216 | 0.83 | ALDH1A1 (0.62) | ALDH1A1L3MBTL1LMNAMAPTKMT2A | |
| SCHEMBL28850052 | 0.82 | TDP1 (0.50) | ALDH1A1L3MBTL1LMNAMAPTKMT2A | |
| Bicarbonate SCHEMBL11748879 | 0.82 | CA2 (0.61) | ALDH1A1L3MBTL1LMNAMAPTCA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100255934-A1 | COMPOSITIONS FOR GOLF EQUIPMENT | ACUSHNET COMPANY | 2010-10-07 | — | — | US | disclosed |
| US-7709590-B2 | Compositions for golf equipment | ACUSHNET COMPANY (US) | 2010-05-04 | — | — | US | disclosed |
| US-7550549-B2 | Compositions for golf equipment | ACUSHNET COMPANY (US) | 2009-06-23 | — | — | US | disclosed |
| US-20080188326-A1 | Compositions for Golf Equipment | ACUSHNET COMPANY | 2008-08-07 | — | — | US | disclosed |
| US-7378483-B2 | Compositions for golf equipment | ACUSHNET COMPANY (US) | 2008-05-27 | — | — | US | disclosed |
| US-20080064527-A1 | Compositions for golf equipment | JPMORGAN CHASE BANK, N.A., AS SUCCESSOR ADMINISTRATIVE AGENT | 2008-03-13 | — | — | US | disclosed |
| US-7276570-B2 | Compositions for golf equipment | ACUSHNET COMPANY (US) | 2007-10-02 | — | — | US | disclosed |
| US-7265195-B2 | Compositions for golf equipment | ACUSHNET COMPANY (US) | 2007-09-04 | — | — | US | disclosed |
| US-7256249-B2 | Compositions for golf equipment | ACUSHNET COMPANY (US) | 2007-08-14 | — | — | US | disclosed |
| US-7253242-B2 | Compositions for golf equipment | ACUSHNET COMPANY (US) | 2007-08-07 | — | — | US | disclosed |
| US-20050004325-A1 | Compositions for golf equipment | JPMORGAN CHASE BANK, N.A., AS SUCCESSOR ADMINISTRATIVE AGENT | 2005-01-06 | — | — | US | disclosed |
| US-20040220356-A1 | Compositions for golf equipment | JPMORGAN CHASE BANK, N.A., AS SUCCESSOR ADMINISTRATIVE AGENT | 2004-11-04 | — | — | US | disclosed |
| US-20040220378-A1 | Compositions for golf equipment | JPMORGAN CHASE BANK, N.A., AS SUCCESSOR ADMINISTRATIVE AGENT | 2004-11-04 | — | — | US | disclosed |
| US-20040220377-A1 | Compositions for golf equipment | JPMORGAN CHASE BANK, N.A., AS SUCCESSOR ADMINISTRATIVE AGENT | 2004-11-04 | — | — | US | disclosed |
| US-20040220373-A1 | Compositions for golf equipment | JPMORGAN CHASE BANK, N.A., AS SUCCESSOR ADMINISTRATIVE AGENT | 2004-11-04 | — | — | US | disclosed |
| US-20040220376-A1 | Compositions for golf equipment | JPMORGAN CHASE BANK, N.A., AS SUCCESSOR ADMINISTRATIVE AGENT | 2004-11-04 | — | — | US | disclosed |
| US-20040220371-A1 | Compositions for golf equipment | JPMORGAN CHASE BANK, N.A., AS SUCCESSOR ADMINISTRATIVE AGENT | 2004-11-04 | — | — | US | disclosed |
| US-20040220357-A1 | Compositions for golf equipment | JPMORGAN CHASE BANK, N.A., AS SUCCESSOR ADMINISTRATIVE AGENT | 2004-11-04 | — | — | US | disclosed |
| US-20040220375-A1 | Compositions for golf equipment | JPMORGAN CHASE BANK, N.A., AS SUCCESSOR ADMINISTRATIVE AGENT | 2004-11-04 | — | — | US | disclosed |
| US-3954718-A | Process for preparing polymers containing carbamoyl-hydroxamate groups and the resultant polymers | STANFORD RESEARCH INSTITUTE (US) | 1976-05-04 | — | — | US | disclosed |