Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLG | P00747 | 4/20 | 0.38 |
| ▸ | PLAU | P00749 | 4/20 | 0.38 |
| ▸ | PLAT | P00750 | 4/20 | 0.38 |
| ▸ | EDNRB | P24530 | 13/20 | 0.36 |
| ▸ | EDNRA | P25101 | 13/20 | 0.36 |
| ▸ | TRPV3 | Q8NET8 | 2/20 | 0.36 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7424712 | 0.75 | ADORA2A (0.42) | TRPV3 | |
| SCHEMBL1281889 | 0.73 | TSHR (0.43) | EDNRBEDNRA | |
| SCHEMBL3275823 | 0.72 | TRPV3 (0.54) | TRPV3P2RX3 | |
| SCHEMBL4538300 | 0.72 | MBOAT4 (0.47) | TRPV3 | |
| SCHEMBL30242161 | 0.72 | MBOAT4 (0.47) | TRPV3 | |
| SCHEMBL6215677 | 0.71 | TSHR (0.47) | PLGPLAUPLAT | |
| SCHEMBL27832398 | 0.70 | NPSR1 (0.41) | — | |
| SCHEMBL27725052 | 0.70 | TSHR (0.37) | TRPV3 | |
| SCHEMBL15486343 | 0.69 | KMT2A (0.49) | — | |
| SCHEMBL19542 | 0.69 | KDM1A (0.44) | TRPV3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8486970-B2 | Tetrahydroisoquinolin-1-one derivative or salt thereof | SELDAR PHARMA INC. (US) | 2013-07-16 | — | — | US | disclosed |
| US-20100227866-A1 | TETRAHYDROISOQUINOLIN-1-ONE DERIVATIVE OR SALT THEREOF | ASTELLAS PHARMA INC. (JP) | 2010-09-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100227866-A1 | TETRAHYDROISOQUINOLIN-1-ONE DERIVATIVE OR SALT THEREOF | BRS3, BDKRB2, NTSR2 | PLG 3513/4885PLAU 1340/4885PLAT 3341/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.