Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.38 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL909006 | 1.00 | P2RX7 (0.45) | P2RX7PKMHSP90AB1KMT2ASMN1; SMN2 | |
| SCHEMBL19925456 | 0.87 | SMN1; SMN2 (0.42) | P2RX7PKMHSP90AB1KMT2ASMN1; SMN2 | |
| SCHEMBL712034 | 0.84 | PTGS2 (0.45) | P2RX7PKMKMT2AMEN1ALDH1A1 | |
| SCHEMBL5383644 | 0.84 | PKM (0.42) | P2RX7PKMKMT2AALDH1A1KDM4E | |
| SCHEMBL14186623 | 0.83 | GAA (0.46) | HSP90AB1KMT2ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL3967997 | 0.83 | SMN1; SMN2 (0.48) | P2RX7PKMHSP90AB1SMN1; SMN2ALDH1A1 | |
| SCHEMBL30106457 | 0.83 | HPGD (0.42) | HSP90AB1KMT2ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL10833911 | 0.83 | HPGD (0.42) | HSP90AB1KMT2ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL29836179 | 0.83 | SMN1; SMN2 (0.48) | P2RX7PKMHSP90AB1SMN1; SMN2ALDH1A1 | |
| SCHEMBL14354579 | 0.81 | ALDH1A1 (0.53) | PKMHSP90AB1KMT2ASMN1; SMN2HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119730853-A | MTA synergistic PRMT5 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2025-03-28 | — | — | CN | disclosed |
| CN-117916241-A | Spiro compounds | 阿斯利康(瑞典)有限公司 | 2024-04-19 | — | — | CN | disclosed |