Sugi Predict

Sugi Predict / Compounds / SCHEMBL909006

SCHEMBL909006

SCHEMBL909006

COC(=O)Cc1ccc(F)cc1Br

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ P2RX7 Q99572 2/20 0.45
▸ PKM P14618 1/20 0.44
▸ HSP90AB1 P08238 1/20 0.40
▸ KMT2A Q03164 3/20 0.39
▸ SMN1; SMN2 Q16637 2/20 0.39
▸ MEN1 O00255 1/20 0.39
▸ HDAC3 O15379 1/20 0.39
▸ HDAC1 Q13547 1/20 0.39
▸ HDAC2 Q92769 1/20 0.39
▸ HDAC6 Q9UBN7 1/20 0.39
▸ ALDH1A1 P00352 4/20 0.38
▸ GAA P10253 3/20 0.38
▸ KDM4E B2RXH2 3/20 0.38
▸ MTNR1A P48039 1/20 0.38
▸ MTNR1B P49286 1/20 0.38
▸ EGFR P00533 1/20 0.38
▸ CYP4F2 P78329 1/20 0.38
▸ CYP4A11 Q02928 1/20 0.38
▸ GLA P06280 1/20 0.38
▸ L3MBTL1 Q9Y468 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30883124 1.00 P2RX7 (0.45) P2RX7PKMHSP90AB1KMT2ASMN1; SMN2
SCHEMBL19925456 0.87 SMN1; SMN2 (0.42) P2RX7PKMHSP90AB1KMT2ASMN1; SMN2
SCHEMBL712034 0.84 PTGS2 (0.45) P2RX7PKMKMT2AMEN1ALDH1A1
SCHEMBL5383644 0.84 PKM (0.42) P2RX7PKMKMT2AALDH1A1KDM4E
SCHEMBL14186623 0.83 GAA (0.46) HSP90AB1KMT2ASMN1; SMN2MEN1ALDH1A1
SCHEMBL3967997 0.83 SMN1; SMN2 (0.48) P2RX7PKMHSP90AB1SMN1; SMN2ALDH1A1
SCHEMBL30106457 0.83 HPGD (0.42) HSP90AB1KMT2ASMN1; SMN2MEN1ALDH1A1
SCHEMBL10833911 0.83 HPGD (0.42) HSP90AB1KMT2ASMN1; SMN2MEN1ALDH1A1
SCHEMBL29836179 0.83 SMN1; SMN2 (0.48) P2RX7PKMHSP90AB1SMN1; SMN2ALDH1A1
SCHEMBL14354579 0.81 ALDH1A1 (0.53) PKMHSP90AB1KMT2ASMN1; SMN2HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 151 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115772141-A Synthetic method of aryl-containing piperidine derivative Boc piperidine 4-fluorophenylethanol 苏州汉德创宏生化科技有限公司 2023-03-10 — — CN claimed
US-20260048040-A1 MTA-COOPERATIVE PRMT5 INHIBITORS FOR USE IN THE TREATMENT OF CANCER ASTRAZENECA AB (SE) 2026-02-19 — — US disclosed
EP-4572760-A1 MTA-COOPERATIVE PRMT5 INHIBITORS FOR USE IN THE TREATMENT OF CANCER Astrazeneca AB (SE) 2025-06-25 — — EP disclosed
US-20240270757-A1 SPIROCYCLIC COMPOUNDS ASTRAZENECA AB (SE) 2024-08-15 — — US disclosed
EP-4402143-A1 SPIROCYCLIC COMPOUNDS Astrazeneca AB (SE) 2024-07-24 — — EP disclosed
CN-117980325-A Modulators of G-protein coupled receptors 卡莫特治疗学股份有限公司 2024-05-03 — — CN disclosed
CN-117916241-A Spiro compounds 阿斯利康(瑞典)有限公司 2024-04-19 — — CN disclosed
US-11939344-B2 Spirocyclic compounds ASTRAZENECA AB (SE) 2024-03-26 — — US disclosed
WO-2024038004-A1 MTA-COOPERATIVE PRMT5 INHIBITORS FOR USE IN THE TREATMENT OF CANCER ASTRAZENECA AB (SE) 2024-02-22 — — WO disclosed
WO-2024038004-A1 MTA-COOPERATIVE PRMT5 INHIBITORS FOR USE IN THE TREATMENT OF CANCER ASTRAZENECA AB (SE) 2024-02-22 — — WO disclosed
US-20110009619-A1 POLYCYCLIC COMPOUND EISAI R&D MANAGEMENT CO., LTD. (JP) 2011-01-13 — — US disclosed
US-20100168095-A1 MULTI-CYCLIC CINNAMIDE DERIVATIVES KIMURA TEIJI 2010-07-01 — — US disclosed
US-7713993-B2 Multi-cycle cinnamide derivatives EISAI R&D MANAGEMENT CO., LTD. (JP) 2010-05-11 — — US disclosed
EP-2181992-A1 POLYCYCLIC COMPOUND Eisai R&D Management Co., Ltd. (JP) 2010-05-05 — — EP disclosed
CN-101400657-A Polycyclic cinnamamide derivative ESAI R & D MAN CO LTD (JP) 2009-04-01 — — CN disclosed
US-20090062529-A1 MULTI-CYCLIC COMPOUNDS EISAI R&D MANAGEMENT CO., LTD., (JP) 2009-03-05 — — US disclosed
EP-1992618-A1 POLYCYCLIC CINNAMIDE DERIVATIVE Eisai R&D Management Co., Ltd. (JP) 2008-11-19 — — EP disclosed
US-20070219181-A1 Multi-cyclic cinnamide derivatives EISAI R&D MANAGEMENT CO., LTD. 2007-09-20 — — US disclosed
CN-1029963-C Process for preparing benzo-naphtho-derivatives of thiazines or oxazines TANABE SEIYAKU CO (JP) 1995-10-11 — — CN disclosed
CN-1054065-A Thiazine or  oxazine derivative and preparation method thereof TANABE SEIYAKU CO (JP) 1991-08-28 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260048040-A1 MTA-COOPERATIVE PRMT5 INHIBITORS FOR USE IN THE TREATMENT OF CANCER PRMT5, PRMT6, PRMT1 P2RX7 4244/4885PKM 2286/4885HSP90AB1 3716/4885
US-20110009619-A1 POLYCYCLIC COMPOUND APP, BACE1, PSEN1 P2RX7 1890/4885PKM 4734/4885HSP90AB1 2065/4885
US-20240270757-A1 SPIROCYCLIC COMPOUNDS PKD1, PKD2, CCNI P2RX7 3797/4885PKM 260/4885HSP90AB1 907/4885
US-20070219181-A1 Multi-cyclic cinnamide derivatives BACE1, APP, PSEN1 P2RX7 1195/4885PKM 4772/4885HSP90AB1 1438/4885
US-20100168095-A1 MULTI-CYCLIC CINNAMIDE DERIVATIVES BACE1, APP, PSEN1 P2RX7 1195/4885PKM 4772/4885HSP90AB1 1438/4885
US-11939344-B2 Spirocyclic compounds PKD1, PKD2, NR5A1 P2RX7 3939/4885PKM 237/4885HSP90AB1 893/4885
US-20090062529-A1 MULTI-CYCLIC COMPOUNDS APP, BACE1, PSEN1 P2RX7 2059/4885PKM 4786/4885HSP90AB1 1099/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.