E626

E626

SCHEMBL308957

Nc1nc2c(ncn2[C@@H]2O[C@H](COP(=O)(O)O)[C@@H](O)[C@H]2O)c(=O)[nH]1.c1c[nH]cn1

nearest known ligand 0.71

Full drug profile on Sugi Atlas →

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
NT5E P21589 1/20 0.71
TGM2 P21980 1/20 0.66
IMPDH2 P12268 7/20 0.65
IMPDH1 P20839 2/20 0.65
TAS1R3 Q7RTX0 2/20 0.62
TAS1R1 Q7RTX1 2/20 0.62
GSK3A P49840 2/20 0.62
RPS6KA3 P51812 2/20 0.62
MAPK14 Q16539 2/20 0.62
KRAS P01116 4/20 0.60
FUT5 Q11128 1/20 0.59
HINT1 P49773 1/20 0.59
CA5A P35218 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Imidazole SCHEMBL1092329 0.94 TGM2 (0.71) NT5ETGM2IMPDH2IMPDH1GSK3A
Guanosine Triphosphate SCHEMBL22658532 0.93 TGM2 (0.70) NT5ETGM2IMPDH2IMPDH1GSK3A
E626 SCHEMBL9980018 0.91 NT5E (0.83) NT5ETGM2IMPDH2IMPDH1TAS1R3
E626 SCHEMBL21163348 0.91 NT5E (0.83) NT5ETGM2IMPDH2IMPDH1TAS1R3
E626 SCHEMBL18763818 0.91 NT5E (0.83) NT5ETGM2IMPDH2IMPDH1TAS1R3
E626 SCHEMBL18759049 0.91 NT5E (0.83) NT5ETGM2IMPDH2IMPDH1TAS1R3
E626 SCHEMBL21803790 0.91 NT5E (0.83) NT5ETGM2IMPDH2IMPDH1TAS1R3
E626 SCHEMBL13497991 0.91 NT5E (0.83) NT5ETGM2IMPDH2IMPDH1TAS1R3
E626 SCHEMBL20677331 0.91 NT5E (0.83) NT5ETGM2IMPDH2IMPDH1TAS1R3
E626 SCHEMBL20276926 0.91 NT5E (0.83) NT5ETGM2IMPDH2IMPDH1TAS1R3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119306779-A R-configuration-containing initial capping oligonucleotide primer and synthesis method thereof 上海科泽永欣生物科技有限公司 2025-01-14 CN claimed
CN-119241624-A Initial capping oligonucleotide primer containing HNA structure and preparation method and application thereof 上海科泽永欣生物科技有限公司 2025-01-03 CN claimed
CN-119306779-A R-configuration-containing initial capping oligonucleotide primer and synthesis method thereof 上海科泽永欣生物科技有限公司 2025-01-14 CN disclosed
CN-119241624-A Initial capping oligonucleotide primer containing HNA structure and preparation method and application thereof 上海科泽永欣生物科技有限公司 2025-01-03 CN disclosed
US-10696709-B2 Phosphotriazole MRNA 5′-end cap analogs, composition comprising the same, RNA molecule incorporating the same, uses thereof and method of synthesizing RNA molecule, protein or peptide UNIWERSYTET WARSZAWSKI (PL) 2020-06-30 US disclosed
EP-3484907-B1 NOVEL PHOSPHOTRIAZOLE MRNA 5'-END CAP ANALOGS, COMPOSITION COMPRISING THE SAME, RNA MOLECULE INCORPORATING THE SAME, USES THEREOF AND METHOD OF SYNTHESIZING RNA MOLECULE, PROTEIN OR PEPTIDE UNIV WARSZAWSKI (PL) 2020-05-13 EP disclosed
US-20200055891-A1 NOVEL PHOSPHOTRIAZOLE MRNA 5'-END CAP ANALOGS, COMPOSITION COMPRISING THE SAME, RNA MOLECULE INCORPORATING THE SAME, USES THEREOF AND METHOD OF SYNTHESIZING RNA MOLECULE, PROTEIN OR PEPTIDE UNIWERSYTET WARSZAWSKI (PL) 2020-02-20 US disclosed
EP-3484907-A1 NOVEL PHOSPHOTRIAZOLE MRNA 5'-END CAP ANALOGS, COMPOSITION COMPRISING THE SAME, RNA MOLECULE INCORPORATING THE SAME, USES THEREOF AND METHOD OF SYNTHESIZING RNA MOLECULE, PROTEIN OR PEPTIDE Uniwersytet Warszawski (PL) 2019-05-22 EP disclosed
WO-2018015845-A1 NOVEL PHOSPHOTRIAZOLE MRNA 5'-END CAP ANALOGS, COMPOSITION COMPRISING THE SAME, RNA MOLECULE INCORPORATING THE SAME, USES THEREOF AND METHOD OF SYNTHESIZING RNA MOLECULE, PROTEIN OR PEPTIDE UNIWERSYTET WARSZAWSKI (PL) 2018-01-25 WO disclosed
US-8519110-B2 mRNA cap analogs BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE (US) 2013-08-27 US disclosed
EP-2297175-B1 MRNA CAP ANALOGS UNIV WARSZAWSKI (PL) 2013-08-07 EP disclosed
US-8093367-B2 Preparation and isolation of 5′ capped mRNA APPLIED BIOSYSTEMS, LLC (US) 2012-01-10 US disclosed
US-20110092574-A1 mRNA Cap Analogs NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2011-04-21 US disclosed
EP-2297175-A2 MRNA CAP ANALOGS Uniwersytet Warszawski (PL) 2011-03-23 EP disclosed
US-20100304389-A1 Preparation And Isolation of 5' Capped mRNA Life Technologies Corporation (US) 2010-12-02 US disclosed
US-20100261231-A1 Dinucleotide MRNA CAP Analogs LIFE TECHNOLOGIES CORPORATION, A DELAWARE CORPORATION (US) 2010-10-14 US disclosed
WO-2009149253-A2 MRNA CAP ANALOGS UNIWERSYTET WARSZAWSKI (PL) 2009-12-10 WO disclosed
WO-2009058911-A2 PREPARATION AND ISOLATION OF 5' CAPPED MRNA APPLIED BIOSYSTEMS INC. (US) 2009-05-07 WO disclosed
EP-2049665-A2 DINUCLEOTIDE MRNA CAP ANALOGS Applera Corporation (US) 2009-04-22 EP disclosed
WO-2008016473-A2 DINUCLEOTIDE MRNA CAP ANALOGS APPLERA CORPORATION (US) 2008-02-07 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100304389-A1 Preparation And Isolation of 5' Capped mRNA RNGTT, RNMT, NSUN2 NT5E 795/4885TGM2 3263/4885IMPDH2 1203/4885
US-10696709-B2 Phosphotriazole MRNA 5′-end cap analogs, composition comprising the same, RNA molecule incorporating the same, uses thereof and method of synthesizing RNA molecule, protein or peptide RNGTT, RNMT, NSUN3 NT5E 1027/4885TGM2 3265/4885IMPDH2 1459/4885
US-20100261231-A1 Dinucleotide MRNA CAP Analogs RNGTT, RNMT, NSUN2 NT5E 343/4885TGM2 3982/4885IMPDH2 509/4885
US-20200055891-A1 NOVEL PHOSPHOTRIAZOLE MRNA 5'-END CAP ANALOGS, COMPOSITION COMPRISING THE SAME, RNA MOLECULE INCORPORATING THE SAME, USES THEREOF AND METHOD OF SYNTHESIZING RNA MOLECULE, PROTEIN OR PEPTIDE RNGTT, RNMT, NSUN3 NT5E 867/4885TGM2 3588/4885IMPDH2 1446/4885
US-20110092574-A1 mRNA Cap Analogs RNMT, RNGTT, NSUN2 NT5E 2213/4885TGM2 4619/4885IMPDH2 1238/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.