Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRPS1 | P60891 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30899626 | 0.65 | GGPS1 (0.43) | POLBTGFBR1 | |
| SCHEMBL31748263 | 0.64 | TDP1 (0.63) | POLBCYP11B1CYP11B2LMNAHTT | |
| SCHEMBL31202905 | 0.64 | PRPS1 (0.46) | PRPS1POLBTGFBR1 | |
| SCHEMBL22125589 | 0.62 | GGPS1 (0.41) | POLBLMNAMEN1MAPK1KMT2A | |
| SCHEMBL31698308 | 0.62 | HCAR1 (0.34) | PRPS1TGFBR1 | |
| SCHEMBL17008880 | 0.61 | TGFBR1 (0.37) | POLBTGFBR1 | |
| SCHEMBL30899625 | 0.61 | PRPS1 (0.43) | PRPS1POLBTGFBR1 | |
| SCHEMBL30914204 | 0.61 | NPC1 (0.40) | PRPS1TGFBR1MAPK1 | |
| SCHEMBL31202825 | 0.61 | QPCT (0.43) | POLBTGFBR1LMNASMN1; SMN2MEN1 | |
| SCHEMBL8204588 | 0.60 | POLB (0.53) | POLBCYP11B1CYP11B2LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012068211-A1 | TRICYCLIC INHIBITORS OF PRO-MATRIX METALLOPROTEINASE ACTIVATION | JANSSEN PHARMACEUTICA NV (BE) | 2012-05-24 | — | — | WO | disclosed |