Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.33 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | AGBL2 | Q5U5Z8 | 1/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.32 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30937533 | 0.83 | PLA2G10 (0.36) | KDM4EALDH1A1MAPK1PER2 | |
| SCHEMBL30937538 | 0.75 | PER2 (0.45) | KDM4EALDH1A1HPGDCYP3A4MAPT | |
| SCHEMBL30937655 | 0.73 | ALDH1A1 (0.45) | KDM4EALDH1A1HPGDCYP3A4MAPT | |
| SCHEMBL30937518 | 0.71 | DPP4 (0.38) | KDM4EALDH1A1HPGDCYP3A4MAPT | |
| SCHEMBL30937681 | 0.68 | ACE (0.42) | KDM4EALDH1A1HPGDCYP3A4MAPT | |
| SCHEMBL30937531 | 0.66 | PER2 (0.43) | KDM4EALDH1A1HPGDMAPTMEN1 | |
| SCHEMBL8345781 | 0.65 | TSHR (0.39) | KDM4EALDH1A1CYP3A4CYP1A2CYP2D6 | |
| SCHEMBL30937679 | 0.65 | BRD4 (0.51) | KDM4EALDH1A1CYP3A4CYP1A2CYP2D6 | |
| SCHEMBL5211320 | 0.64 | ITGB3 (0.56) | KDM4EALDH1A1HPGDCYP3A4MAPT | |
| SCHEMBL30937732 | 0.64 | ACE (0.44) | KDM4EALDH1A1HPGDCYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4594307-A1 | 1,4-DIHYDROQUINAZOLINONE COMPOUNDS AND USES THEREOF | EDGEWISE THERAPEUTICS, INC. (US) | 2025-08-06 | — | — | EP | disclosed |
| WO-2024073426-A1 | 1,4-DIHYDROQUINAZOLINONE COMPOUNDS AND USES THEREOF | EDGEWISE THERAPEUTICS, INC. (US) | 2024-04-04 | — | — | WO | disclosed |