Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 5/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 2/20 | 0.34 |
| ▸ | EIF2AK4 | Q9P2K8 | 2/20 | 0.34 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | IDH1 | O75874 | 2/20 | 0.33 |
| ▸ | IDH2 | P48735 | 2/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 3/20 | 0.32 |
| ▸ | MMP12 | P39900 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31634715 | 1.00 | MC4R (0.36) | MC4RDDB1CRBNSYKEIF2AK4 | |
| SCHEMBL31634709 | 0.88 | MC4R (0.40) | MC4RDDB1CRBNSYKEIF2AK4 | |
| SCHEMBL31634713 | 0.85 | GPR119 (0.36) | DDB1CRBNSYKEIF2AK4TBK1 | |
| SCHEMBL31634663 | 0.84 | MC4R (0.47) | MC4RDDB1CRBNCCNT1KCNH2 | |
| SCHEMBL30948968 | 0.82 | MC4R (0.46) | MC4RDDB1CRBNKCNH2MMP12 | |
| SCHEMBL30948967 | 0.82 | MC4R (0.46) | MC4RDDB1CRBNKCNH2MMP12 | |
| SCHEMBL31634680 | 0.82 | MC4R (0.46) | MC4RDDB1CRBNKCNH2MMP12 | |
| SCHEMBL30948963 | 0.81 | MC4R (0.38) | MC4RDDB1CRBNKCNH2IDH1 | |
| SCHEMBL31634661 | 0.81 | MC4R (0.38) | MC4RDDB1CRBNKCNH2IDH1 | |
| SCHEMBL31634671 | 0.78 | KAT8 (0.38) | MC4RDDB1CRBNSYKCCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024104452-A1 | MC4R ANTAGONIST COMPOUND, PHARMACEUTICAL COMPOSITION AND PHARMACEUTICAL USE THEREOF | 长春金赛药业有限责任公司 | 2024-05-23 | — | — | WO | disclosed |