Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 1/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 10/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 10/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 10/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.45 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.45 |
| ▸ | NCOR2 | Q9Y618 | 4/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7455097 | 0.82 | ALDH1A1 (0.50) | MMP2HDAC3HDAC1HDAC2MAPK1 | |
| SCHEMBL653241 | 0.81 | HDAC3 (0.68) | HDAC3HDAC1HDAC2MAPK1NPC1 | |
| SCHEMBL11291980 | 0.80 | NPC1 (0.57) | HDAC3HDAC1HDAC2MAPK1NPC1 | |
| SCHEMBL11290401 | 0.78 | CDC25B (0.58) | HDAC3HDAC1HDAC2MAPK1NPC1 | |
| SCHEMBL20577985 | 0.78 | MEN1 (0.49) | HDAC3HDAC1HDAC2MAPK1NPC1 | |
| SCHEMBL17796923 | 0.78 | HDAC3 (0.50) | HDAC3HDAC1HDAC2MAPK1NPC1 | |
| SCHEMBL564707 | 0.76 | MMP2 (0.45) | MMP2HDAC3HDAC1HDAC2MAPK1 | |
| SCHEMBL14157620 | 0.76 | LMNA (0.46) | MAPK1NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL6820139 | 0.75 | CXCR2 (0.60) | NPC1RAB9ACASP3SENP8SENP7 | |
| SCHEMBL10985405 | 0.74 | MEN1 (0.50) | HDAC3HDAC1HDAC2MAPK1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1661892-B1 | CONDENSED RING COMPOUND AND USE THEREOF | ONO PHARMACEUTICAL CO (JP) | 2013-07-24 | — | — | EP | disclosed |
| US-8318952-B2 | Substituted indole derivatives for the treatment of respiratory diseases | ONO PHARMACEUTICAL CO., LTD. (JP) | 2012-11-27 | — | — | US | disclosed |
| EP-2481732-A1 | Condensed ring compound and use thereof | Ono Pharmaceutical Co., Ltd. (JP) | 2012-08-01 | — | — | EP | disclosed |
| US-20100234368-A1 | CONDENSED RING COMPOUND AND USE THEREOF | TAKEUCHI JUN | 2010-09-16 | — | — | US | disclosed |
| CN-101374818-A | Pyrimidine derivatives | ASTRAZENECA AB (SE) | 2009-02-25 | — | — | CN | disclosed |
| EP-1661892-A1 | CONDENSED RING COMPOUND AND USE THEREOF | ONO PHARMACEUTICAL CO., LTD. (JP) | 2006-05-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100234368-A1 | CONDENSED RING COMPOUND AND USE THEREOF | CYSLTR2, CYSLTR1, LTB4R2 | MMP2 3597/4885HDAC3 1524/4885HDAC1 1733/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.