Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | TET3 | O43151 | 2/20 | 0.51 |
| ▸ | FBXL19 | Q6PCT2 | 2/20 | 0.51 |
| ▸ | CXXC5 | Q7LFL8 | 2/20 | 0.51 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.51 |
| ▸ | CXXC4 | Q9H2H0 | 2/20 | 0.51 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.51 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.51 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.42 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3087224 | 0.87 | KMT2A (0.61) | KMT2ATET3FBXL19CXXC5KDM2B | |
| SCHEMBL3097422 | 0.84 | NPSR1 (0.61) | KMT2ATET3FBXL19CXXC5KDM2B | |
| SCHEMBL3092711 | 0.84 | AKR1C3 (0.57) | KMT2ATET3FBXL19CXXC5KDM2B | |
| SCHEMBL3092705 | 0.84 | AKR1C3 (0.58) | KMT2ATET3FBXL19CXXC5KDM2B | |
| SCHEMBL3091785 | 0.83 | CHRM4 (0.51) | KMT2ATET3FBXL19CXXC5KDM2B | |
| SCHEMBL13092512 | 0.83 | PIN1 (0.47) | KMT2ACHRM4PANK3 | |
| SCHEMBL3098112 | 0.82 | KMT2A (0.52) | KMT2ATET3FBXL19CXXC5KDM2B | |
| SCHEMBL3104324 | 0.80 | OPRD1 (0.51) | KMT2ATET3FBXL19CXXC5KDM2B | |
| SCHEMBL378652 | 0.79 | AKR1C3 (0.59) | KMT2ATET3FBXL19CXXC5KDM2B | |
| SCHEMBL3104354 | 0.77 | SLC6A7 (0.54) | KMT2ATET3FBXL19CXXC5KDM2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8324250-B2 | Piperidine derivatives as NK3 receptor antagonists | HOFFMANN-LA ROCHE INC. (US) | 2012-12-04 | — | — | US | disclosed |
| US-20100256126-A1 | PIPERIDINE DERIVATIVES AS NK3 RECEPTOR ANTAGONISTS | HOFFMANN-LA ROCHE, INC. | 2010-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100256126-A1 | PIPERIDINE DERIVATIVES AS NK3 RECEPTOR ANTAGONISTS | HTR3A, OPRL1, OPRK1 | KMT2A 1488/4885TET3 3957/4885FBXL19 3972/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.