Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | DAO | P14920 | 1/20 | 0.39 |
| ▸ | GABRP | O00591 | 1/20 | 0.38 |
| ▸ | GABRD | O14764 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.38 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.38 |
| ▸ | GABRE | P78334 | 1/20 | 0.38 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.38 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.38 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.38 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | OXTR | P30559 | 4/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23927091 | 0.81 | ALDH1A1 (0.43) | DAOGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL23927079 | 0.81 | HTR1A (0.39) | DAOGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL30079061 | 0.81 | OXTR (0.37) | DAOGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL23927055 | 0.81 | OXTR (0.37) | DAOGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL23927030 | 0.80 | DRD1 (0.40) | DAOGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL30079049 | 0.80 | DRD1 (0.40) | DAOGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL23952721 | 0.79 | GABRP (0.39) | DAOGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL25025704 | 0.79 | GABRP (0.36) | DAOGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL25025657 | 0.79 | DRD1 (0.41) | DAOGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL30794092 | 0.79 | DRD1 (0.41) | DAOGABRPGABRDGABRA1GABRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260125381-A1 | NOVEL Kv3 CHANNEL MODULATORS | MERCK SHARP & DOHME LLC (US) | 2026-05-07 | — | — | US | disclosed |
| EP-4604945-A2 | NOVEL KV3 CHANNEL MODULATORS | Merck Sharp & Dohme LLC (US) | 2025-08-27 | — | — | EP | disclosed |
| WO-2024086061-A2 | NOVEL KV3 CHANNEL MODULATORS | MERCK SHARP & DOHME LLC (US) | 2024-04-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260125381-A1 | NOVEL Kv3 CHANNEL MODULATORS | KCNN3, KCNA3, KCNQ3 | KEAP1 1499/4885DAO 4400/4885GABRP 282/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.