Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.57 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.56 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.51 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.51 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.51 |
| ▸ | GSK3B | P49841 | 4/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14734878 | 0.83 | KDM4E (0.50) | KDM4EPRKAG1PRKAA1PRKAB1GSK3B | |
| SCHEMBL27942416 | 0.82 | PTGS2 (0.47) | KDM4EGSK3BPTGS1PTGS2LMNA | |
| SCHEMBL17232485 | 0.80 | KDM4E (0.50) | KDM4EPRKAG1PRKAA1PRKAB1HSD17B10 | |
| SCHEMBL5988579 | 0.80 | TTK (0.53) | KDM4EGSK3BHSD17B10ALDH1A1HPGD | |
| SCHEMBL8151565 | 0.79 | CNR2 (0.44) | KDM4EAKR1C2PRKAG1PRKAA1PRKAB1 | |
| SCHEMBL17221269 | 0.79 | HTR2B (0.53) | KDM4EPRKAG1PRKAA1PRKAB1HSD17B10 | |
| SCHEMBL9295415 | 0.79 | MTNR1A (0.52) | KDM4EPRKAG1PRKAA1PRKAB1GSK3B | |
| SCHEMBL7581326 | 0.78 | LMNA (0.49) | KDM4EPRKAG1PRKAA1PRKAB1GSK3B | |
| SCHEMBL30965223 | 0.78 | TSHR (0.54) | KDM4EHSD17B10PTGS1ALDH1A1HPGD | |
| SCHEMBL929332 | 0.78 | PRKAG1 (0.79) | KDM4EPRKAG1PRKAA1PRKAB1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024085695-A1 | NOVEL ALTIRATINIB DERIVATIVE, MANUFACTURING METHOD THEREFOR, AND COMPOSITION COMPRISING SAME AS ACTIVE INGREDIENT FOR PREVENTION, ALLEVIATION, OR TREATMENT OF SKIN PIGMENTATION | 재단법인 아산사회복지재단 | 2024-04-25 | — | — | WO | disclosed |