Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | GPR142 | Q7Z601 | 5/20 | 0.32 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.30 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.30 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.30 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30968042 | 0.88 | PTAFR (0.35) | GPR142OPRM1OPRD1 | |
| SCHEMBL30968100 | 0.88 | PTAFR (0.35) | GPR142OPRM1OPRD1 | |
| SCHEMBL30968132 | 0.88 | PTAFR (0.35) | GPR142OPRM1OPRD1 | |
| SCHEMBL31065775 | 0.83 | PLD3 (0.32) | GPR142 | |
| SCHEMBL31065783 | 0.83 | PLD3 (0.32) | GPR142 | |
| SCHEMBL31065780 | 0.83 | PLD3 (0.32) | GPR142 | |
| SCHEMBL31065774 | 0.83 | GPR119 (0.36) | — | |
| SCHEMBL30968006 | 0.83 | GPR119 (0.36) | — | |
| SCHEMBL30967972 | 0.82 | DHODH (0.37) | — | |
| SCHEMBL30967987 | 0.79 | PTAFR (0.36) | GPR142OPRM1OPRD1TLR9TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118239959-A | Cyclopropane TLR7 and 8 inhibitor and preparation method and application thereof | 上海深势唯思科技有限责任公司 | 2024-06-25 | — | — | CN | disclosed |