Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 2/20 | 0.33 |
| ▸ | MAOB | P27338 | 2/20 | 0.33 |
| ▸ | PRKCI | P41743 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 2/20 | 0.32 |
| ▸ | HTR2C | P28335 | 2/20 | 0.32 |
| ▸ | HTR2B | P41595 | 2/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | MTNR1B | P49286 | 6/20 | 0.31 |
| ▸ | MTNR1A | P48039 | 5/20 | 0.31 |
| ▸ | KIF11 | P52732 | 1/20 | 0.31 |
| ▸ | ERN1 | O75460 | 2/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.31 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.30 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10158533 | 0.76 | HTR2C (0.35) | MAOAMAOBHTR2AHTR2CHTR2B | |
| SCHEMBL30754266 | 0.76 | MTNR1B (0.35) | MAOAMAOBPRKCIHTR2AHTR2C | |
| SCHEMBL5546117 | 0.76 | MAOA (0.46) | MAOAMAOBPRKCIHTR2AHTR2C | |
| SCHEMBL1764937 | 0.76 | MTNR1B (0.35) | MAOAMAOBPRKCIHTR2AHTR2C | |
| SCHEMBL3988579 | 0.72 | GABRA1 (0.41) | HTR2AHTR2CHTR2BMTNR1BMTNR1A | |
| SCHEMBL30951346 | 0.72 | NLRP3 (0.38) | MAOAMAOB | |
| SCHEMBL2830923 | 0.71 | ITGB2 (0.42) | MTNR1BMTNR1AKIF11MEN1KMT2A | |
| SCHEMBL21834717 | 0.68 | MTNR1B (0.34) | MAOAMAOBMTNR1BMTNR1AABCB11 | |
| SCHEMBL5506295 | 0.68 | MAOA (0.46) | MAOAMAOBPRKCIHTR2AHTR2C | |
| SCHEMBL3716928 | 0.68 | ALOX5 (0.39) | MAOAMAOBPRKCIHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4642784-A1 | HETEROCYCLIC AND HETEROARYL COMPOUNDS AS INHIBITORS OF NLRP3 | PTC Therapeutics, Inc. (US) | 2025-11-05 | — | — | EP | disclosed |
| WO-2024145623-A1 | HETEROCYCLIC AND HETEROARYL COMPOUNDS AS INHIBITORS OF NLRP3 | PTC THERAPEUTICS, INC. (US) | 2024-07-04 | — | — | WO | disclosed |