Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 6/20 | 0.51 |
| ▸ | GPR6 | P46095 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.42 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.42 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | WDR5 | P61964 | 2/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30989927 | 1.00 | PDE10A (0.51) | PDE10AGPR6KMT2AMEN1TAS1R3 | |
| SCHEMBL30990021 | 0.87 | TAS1R3 (0.57) | PDE10AKMT2AMEN1TAS1R3TAS1R1 | |
| SCHEMBL30989892 | 0.82 | NTRK1 (0.46) | GPR6MAPK1CRHR1 | |
| SCHEMBL30989853 | 0.81 | PDE4A (0.54) | PDE10AKMT2AMEN1TAS1R3TAS1R1 | |
| SCHEMBL30989826 | 0.80 | GPR6 (0.39) | GPR6CRHR1 | |
| SCHEMBL30989846 | 0.79 | GPR6 (0.42) | GPR6CRHR1RIPK1 | |
| SCHEMBL30989877 | 0.77 | TAS1R3 (0.54) | PDE10AKMT2AMEN1TAS1R3TAS1R1 | |
| SCHEMBL25237231 | 0.76 | PDE10A (0.44) | PDE10AKMT2AMEN1TAS1R3TAS1R1 | |
| SCHEMBL30989933 | 0.75 | P2RX7 (0.42) | PDE10AGPR6KMT2AMEN1TAS1R3 | |
| SCHEMBL30989929 | 0.75 | P2RX7 (0.42) | PDE10AGPR6KMT2AMEN1TAS1R3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4612131-A1 | NICOTINAMIDE DERIVATIVES FOR USE IN TREATING DISORDERS ASSOCIATED WITH KCNK13 ACTIVITY | Cerevance, Inc. (US) | 2025-09-10 | — | — | EP | disclosed |
| WO-2024095003-A1 | NICOTINAMIDE DERIVATIVES FOR USE IN TREATING DISORDERS ASSOCIATED WITH KCNK13 ACTIVITY | Cerevance, Inc. (US) | 2024-05-10 | — | — | WO | disclosed |