Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR6 | P46095 | 3/20 | 0.39 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.39 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.38 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.37 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.37 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | SPR | P35270 | 1/20 | 0.36 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.35 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30989798 | 0.91 | PIN1 (0.42) | GPR6TRPM8PIN1PIK3C3ACHE | |
| SCHEMBL30990055 | 0.91 | PIN1 (0.42) | GPR6TRPM8PIN1PIK3C3ACHE | |
| SCHEMBL30989842 | 0.88 | SPR (0.47) | TRPM8PIN1GPBAR1SPR | |
| SCHEMBL30989894 | 0.88 | SPR (0.47) | TRPM8PIN1GPBAR1SPR | |
| SCHEMBL30989893 | 0.87 | GPR6 (0.43) | GPR6GPBAR1IP6K1IMPDH2ACHE | |
| SCHEMBL30989803 | 0.82 | PIN1 (0.48) | GPR6TRPM8PIN1SPR | |
| SCHEMBL30989947 | 0.82 | PIN1 (0.48) | GPR6TRPM8PIN1SPR | |
| SCHEMBL30989905 | 0.82 | KDM4C (0.40) | GPR6GPBAR1PIK3C3 | |
| SCHEMBL30989850 | 0.80 | PDE10A (0.51) | GPR6CRHR1 | |
| SCHEMBL30989927 | 0.80 | PDE10A (0.51) | GPR6CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4612131-A1 | NICOTINAMIDE DERIVATIVES FOR USE IN TREATING DISORDERS ASSOCIATED WITH KCNK13 ACTIVITY | Cerevance, Inc. (US) | 2025-09-10 | — | — | EP | claimed |
| WO-2024095003-A1 | NICOTINAMIDE DERIVATIVES FOR USE IN TREATING DISORDERS ASSOCIATED WITH KCNK13 ACTIVITY | Cerevance, Inc. (US) | 2024-05-10 | — | — | WO | claimed |
| EP-4612131-A1 | NICOTINAMIDE DERIVATIVES FOR USE IN TREATING DISORDERS ASSOCIATED WITH KCNK13 ACTIVITY | Cerevance, Inc. (US) | 2025-09-10 | — | — | EP | disclosed |
| WO-2024095003-A1 | NICOTINAMIDE DERIVATIVES FOR USE IN TREATING DISORDERS ASSOCIATED WITH KCNK13 ACTIVITY | Cerevance, Inc. (US) | 2024-05-10 | — | — | WO | disclosed |