Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 5/20 | 0.52 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | HSD17B2 | P37059 | 3/20 | 0.39 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.39 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | GHSR | Q92847 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TACR1 | P25103 | 2/20 | 0.37 |
| ▸ | PLAU | P00749 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30989806 | 0.92 | GRM5 (0.45) | HSP90AA1GRM5HTTKMT2ATACR1 | |
| SCHEMBL30989812 | 0.91 | MEP1B (0.44) | HSP90AA1GRM5HSD17B2HTTKMT2A | |
| SCHEMBL30989923 | 0.90 | ALDH1A1 (0.47) | HSP90AA1GRM5HSD17B2HSD17B1HTT | |
| SCHEMBL30989922 | 0.88 | POLB (0.49) | HSD17B2KMT2A | |
| SCHEMBL30989807 | 0.87 | TACR1 (0.47) | PDK1TACR1 | |
| SCHEMBL30989865 | 0.86 | PTGER4 (0.41) | HSP90AA1GRM5HSD17B2HSD17B1PDK1 | |
| SCHEMBL30989861 | 0.86 | RIPK1 (0.49) | PDK1HTT | |
| SCHEMBL30989912 | 0.86 | HTT (0.37) | HSP90AA1GRM5HTTTACR1 | |
| SCHEMBL30989808 | 0.83 | HTT (0.39) | HSP90AA1GRM5HTTTACR1 | |
| SCHEMBL30989793 | 0.81 | HTT (0.38) | HSP90AA1GRM5HTTKMT2ATACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4612131-A1 | NICOTINAMIDE DERIVATIVES FOR USE IN TREATING DISORDERS ASSOCIATED WITH KCNK13 ACTIVITY | Cerevance, Inc. (US) | 2025-09-10 | — | — | EP | disclosed |
| WO-2024095003-A1 | NICOTINAMIDE DERIVATIVES FOR USE IN TREATING DISORDERS ASSOCIATED WITH KCNK13 ACTIVITY | Cerevance, Inc. (US) | 2024-05-10 | — | — | WO | disclosed |