Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.48 |
| ▸ | HSD17B2 | P37059 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30989812 | 0.95 | MEP1B (0.44) | POLBHPGDRECQLROCK1ROCK2 | |
| SCHEMBL30989861 | 0.90 | RIPK1 (0.49) | POLBHPGDRECQLROCK1ROCK2 | |
| SCHEMBL30989806 | 0.90 | GRM5 (0.45) | HPGDRECQLMEN1KMT2AALDH1A1 | |
| SCHEMBL30989923 | 0.88 | ALDH1A1 (0.47) | HPGDHSD17B2MEN1KMT2AALDH1A1 | |
| SCHEMBL30989857 | 0.88 | HSP90AA1 (0.52) | HSD17B2KMT2A | |
| SCHEMBL30989807 | 0.85 | TACR1 (0.47) | HPGDLMNA | |
| SCHEMBL30989865 | 0.85 | PTGER4 (0.41) | HSD17B2 | |
| SCHEMBL30989808 | 0.81 | HTT (0.39) | HPGDALDH1A1 | |
| SCHEMBL30989909 | 0.81 | CLK1 (0.48) | POLBHPGDRECQLROCK1ROCK2 | |
| SCHEMBL30989793 | 0.80 | HTT (0.38) | HPGDMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4612131-A1 | NICOTINAMIDE DERIVATIVES FOR USE IN TREATING DISORDERS ASSOCIATED WITH KCNK13 ACTIVITY | Cerevance, Inc. (US) | 2025-09-10 | — | — | EP | disclosed |
| WO-2024095003-A1 | NICOTINAMIDE DERIVATIVES FOR USE IN TREATING DISORDERS ASSOCIATED WITH KCNK13 ACTIVITY | Cerevance, Inc. (US) | 2024-05-10 | — | — | WO | disclosed |