Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | PYGL | P06737 | 1/20 | 0.36 |
| ▸ | WDR5 | P61964 | 2/20 | 0.36 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.35 |
| ▸ | NHERF1 | O14745 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 4/20 | 0.34 |
| ▸ | JAK1 | P23458 | 4/20 | 0.34 |
| ▸ | TYK2 | P29597 | 4/20 | 0.34 |
| ▸ | HAT1 | O14929 | 1/20 | 0.34 |
| ▸ | EP300 | Q09472 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | F7 | P08709 | 1/20 | 0.33 |
| ▸ | F3 | P13726 | 1/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30993716 | 0.79 | CREBBP (0.41) | PYGLWDR5NR4A2NHERF1NPC1 | |
| SCHEMBL30993751 | 0.76 | POLB (0.36) | POLBPYGLNR4A2NHERF1NPC1 | |
| SCHEMBL30993024 | 0.75 | TYK2 (0.42) | PYGLNR4A2NHERF1NPC1TYK2 | |
| SCHEMBL30993573 | 0.70 | HTT (0.39) | POLBNPC1SMN1; SMN2KMT2A | |
| SCHEMBL30993163 | 0.69 | CREBBP (0.39) | PYGLNR4A2NPC1KMT2AHAT1 | |
| SCHEMBL31375034 | 0.67 | F7 (0.51) | NR4A2NHERF1NPC1KMT2AF7 | |
| SCHEMBL24457823 | 0.66 | WDR5 (0.43) | POLBWDR5SMN1; SMN2KMT2AKCNH2 | |
| SCHEMBL27648661 | 0.66 | BRPF1 (0.39) | PYGLNR4A2NHERF1NPC1KMT2A | |
| SCHEMBL30993273 | 0.66 | AR (0.34) | PYGLNR4A2NPC1HAT1EP300 | |
| SCHEMBL15680292 | 0.66 | CSNK2A2 (0.40) | POLBTP53TDP1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024130095-A1 | COMPOUNDS AND COMPOSITIONS AS CBP/P300 DEGRADERS AND USES THEREOF | REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2024-06-20 | — | — | WO | disclosed |