SCHEMBL3100182

SCHEMBL3100182

CN1C(=O)NC(c2ccccc2)(c2ccccc2)C1=O

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.59
CYP2C19 P33261 1/20 0.59
POLB P06746 2/20 0.54
TDP1 Q9NUW8 1/20 0.50
LMNA P02545 1/20 0.49
HRH1 P35367 2/20 0.48
FAAH O00519 1/20 0.48
HRH3 Q9Y5N1 1/20 0.48
CACNA1F O60840 1/20 0.47
ALDH1A1 P00352 1/20 0.47
MAPT P10636 1/20 0.47
CYP2C9 P11712 1/20 0.47
HTR2A P28223 1/20 0.47
SCN1A P35498 1/20 0.47
SCN4A P35499 1/20 0.47
BLM P54132 1/20 0.47
PMP22 Q01453 1/20 0.47
CACNA1D Q01668 1/20 0.47
KCNH2 Q12809 1/20 0.47
CACNA1S Q13698 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15966185 0.87 BACE1 (0.50) TSHRCYP2C19POLBTDP1LMNA
SCHEMBL20290106 0.86 TSHR (0.47) TSHRCYP2C19POLBTDP1FAAH
SCHEMBL7531542 0.83 POLB (0.46) TSHRCYP2C19POLBTDP1LMNA
SCHEMBL29763558 0.83 FAAH (0.58) TSHRCYP2C19POLBTDP1HRH1
SCHEMBL4439923 0.82 CNR1 (0.46) TSHRCYP2C19POLBTDP1LMNA
SCHEMBL4436971 0.82 CNR1 (0.46) TSHRCYP2C19POLBTDP1LMNA
SCHEMBL11885823 0.77 TDP1 (0.63) POLBTDP1HRH1HRH3SIGMAR1
SCHEMBL11885815 0.77 POLB (0.63) POLBTDP1HRH1FAAHHRH3
SCHEMBL7533808 0.77 POLB (0.41) TSHRCYP2C19POLBTDP1LMNA
SCHEMBL1461591 0.76 TDP1 (0.54) POLBTDP1HRH1HRH3CACNA1F

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0900227-B1 IMPROVED PROCESS FOR THE SYNTHESIS OF DIESTERS OF PHOSPHORIC ACID 2,5-DIOXO-4,4-DIPHENYL-IMIDAZOLIDIN-1-YLMETHYL ESTER WARNER LAMBERT CO (US) 2001-12-12 EP claimed
EP-0680469-B1 AMINOACID DERIVATES, MEDICAMENTS CONTAINING THESE COMPOUNDS AND PROCESS FOR PREPARING THE SAME BOEHRINGER INGELHEIM PHARMA (DE) 2000-04-26 EP claimed
EP-0040224-A4 AN IMPROVED METHOD OF NON HOMOGENOUS ENZYME IMMUNOASSAY. PRINCE CHARLES HOSPITAL DEV CT (AU) 1982-09-09 EP claimed
EP-0040224-A1 AN IMPROVED METHOD OF NON HOMOGENOUS ENZYME IMMUNOASSAY THE PRINCE CHARLES HOSPITAL DEVELOPMENT CENTRE TRUST (AU) 1981-11-25 EP claimed
WO-1981001414-A1 AN IMPROVED METHOD OF NON HOMOGENOUS ENZYME IMMUNOASSAY CHARLES HOSPITAL DEV (AU) 1981-05-28 WO claimed
US-12565499-B2 Compounds and methods INTRA-CELLULAR THERAPIES, INC. (US) 2026-03-03 US disclosed
US-20240208974-A1 NOVEL COMPOUNDS AND METHODS INTRA-CELLULAR THERAPIES, INC. (US) 2024-06-27 US disclosed
US-11958852-B2 Compounds and methods INTRA-CELLULAR THERAPIES, INC. (US) 2024-04-16 US disclosed
US-20230279048-A1 COMPOSITIONS CONTAINING HC-HA/PTX3 COMPLEXES AND METHODS OF USE THEREOF U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION 2023-09-07 US disclosed
EP-3772362-B1 DEVICE FOR MAGNETIC FIELD STIMULATION OF BODY TISSUE OF A USER FOR USE IN DIGITAL TELEMEDICINE, IN PARTICULAR ACCORDING TO THE E-PULS METHOD FOR PELVIC FLOOR OPTIMISATION PROF DR FISCHER AG (LI) 2022-12-21 EP disclosed
US-11518782-B2 Compositions containing HC-HA/PTX3 complexes and methods of use thereof TISSUETECH, INC. (US) 2022-12-06 US disclosed
US-11439675-B2 Method for treating damage induced by sleep deprivation PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2022-09-13 US disclosed
WO-2009017259-A1 A MEDICAMENT FOR TREATING GLAUCOMA COMPRISING AS AN ACTIVE INGREDIENT CYCLODEXTRIN-CLATHRATE COMPOUND OF CILOSTAZOL OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2009-02-05 WO disclosed
US-20040223983-A1 Pharmaceutical preparations, use of these preparations and process for increasing the biovailability of pharmaceutical substances to be administered perorally BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) 2004-11-11 US disclosed
US-5807875-A OBESITY THERAPY DR. KARL THOMAE GMBH (DE) 1998-09-15 US disclosed
US-5616620-A HYPOTENSIVE AGENTS KARL THOMAE GMBH (DE) 1997-04-01 US disclosed
EP-0040224-A4 AN IMPROVED METHOD OF NON HOMOGENOUS ENZYME IMMUNOASSAY. PRINCE CHARLES HOSPITAL DEV CT (AU) 1982-09-09 EP disclosed
US-4348204-A COTTON, REGENERATED CELLULOSE, PAPER; TETRAKISAZO DYES CASSELLA AKTIENGESELLSCHAFT (DE) 1982-09-07 US disclosed
EP-0040224-A1 AN IMPROVED METHOD OF NON HOMOGENOUS ENZYME IMMUNOASSAY THE PRINCE CHARLES HOSPITAL DEVELOPMENT CENTRE TRUST (AU) 1981-11-25 EP disclosed
WO-1981001414-A1 AN IMPROVED METHOD OF NON HOMOGENOUS ENZYME IMMUNOASSAY CHARLES HOSPITAL DEV (AU) 1981-05-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12565499-B2 Compounds and methods PSEN1, CHAT, SNCA TSHR 1412/4885CYP2C19 308/4885POLB 1426/4885
US-11439675-B2 Method for treating damage induced by sleep deprivation SI, CRY2, PER2 TSHR 4551/4885CYP2C19 1909/4885POLB 689/4885
US-20240208974-A1 NOVEL COMPOUNDS AND METHODS GRIN2C, CHAT, CHRNA5 TSHR 2185/4885CYP2C19 314/4885POLB 1010/4885
US-11958852-B2 Compounds and methods GRIN2C, HTR2C, CHAT TSHR 2513/4885CYP2C19 229/4885POLB 1154/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.