Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICMT | O60725 | 2/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.51 |
| ▸ | ITGB1 | P05556 | 6/20 | 0.47 |
| ▸ | ITGA4 | P13612 | 6/20 | 0.47 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.46 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.44 |
| ▸ | PTPRC | P08575 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.44 |
| ▸ | PSMB2 | P49721 | 2/20 | 0.44 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | DHPS | P49366 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.42 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29283855 | 1.00 | ICMT (0.51) | ICMTROCK2ROCK1ITGB1ITGA4 | |
| SCHEMBL29283832 | 0.89 | HSP90AB1 (0.60) | ICMTROCK2ROCK1ITGB1ITGA4 | |
| SCHEMBL29283799 | 0.84 | LMNA (0.46) | ROCK2ROCK1P2RX7PTPRCPTPN1 | |
| SCHEMBL31006544 | 0.84 | LMNA (0.46) | ROCK2ROCK1P2RX7PTPRCPTPN1 | |
| SCHEMBL29283819 | 0.83 | ROCK2 (0.60) | ROCK2ROCK1HSP90AB1LMNAGRM2 | |
| SCHEMBL31006514 | 0.83 | ROCK2 (0.60) | ROCK2ROCK1HSP90AB1LMNAGRM2 | |
| SCHEMBL31006533 | 0.82 | HSP90AB1 (0.48) | ROCK2ROCK1HSP90AB1LMNADHPS | |
| SCHEMBL29283815 | 0.82 | HSP90AB1 (0.48) | ROCK2ROCK1HSP90AB1PTPRCPTPN1 | |
| SCHEMBL31006510 | 0.82 | HSP90AB1 (0.48) | ROCK2ROCK1HSP90AB1PTPRCPTPN1 | |
| SCHEMBL29283840 | 0.82 | HSP90AB1 (0.48) | ROCK2ROCK1HSP90AB1LMNADHPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118184635-A | Quinolinone compound, pharmaceutical composition and application thereof | 安徽医科大学 | 2024-06-14 | — | — | CN | disclosed |