Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.39 |
| ▸ | AXL | P30530 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.39 |
| ▸ | PTPN5 | P54829 | 3/20 | 0.39 |
| ▸ | HSPD1 | P10809 | 2/20 | 0.39 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4780299 | 0.91 | CYP3A4 (0.41) | HSP90AA1HSP90AB1DYRK1ALMNASMN1; SMN2 | |
| SCHEMBL4781817 | 0.87 | SLC40A1 (0.48) | HSP90AA1HSP90AB1KDRAURKBPIK3C2B | |
| SCHEMBL4778521 | 0.86 | SLC40A1 (0.51) | LMNAKMT2AMEN1PTPN1PTPN5 | |
| SCHEMBL4781517 | 0.83 | MEN1 (0.41) | HSP90AA1HSP90AB1KDRKMT2APOLB | |
| SCHEMBL4781338 | 0.78 | SLC40A1 (0.48) | LMNASMN1; SMN2KMT2AMEN1PTPN1 | |
| SCHEMBL4779280 | 0.78 | SLC40A1 (0.51) | LMNAAXLKMT2AMEN1PTPN1 | |
| SCHEMBL3098055 | 0.78 | AXL (0.52) | CYP3A4AXLKMT2AMEN1CYP2C9 | |
| SCHEMBL4795831 | 0.77 | SLC40A1 (0.55) | LMNAKMT2AMEN1PTPN1PTPN5 | |
| SCHEMBL4780017 | 0.76 | KAT6A (0.39) | KAT6AKMT2AMEN1PKMBRAF | |
| SCHEMBL3091703 | 0.76 | CCR9 (0.43) | KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008008374-A2 | CCR2 INHIBITORS AND METHODS OF USE THEREOF | CHEMOCENTRYX, INC. (US) | 2008-01-17 | — | — | WO | claimed |
| US-20100234364-A1 | CCR2 INHIBITORS AND METHODS OF USE THEREOF | CHEMOCENTRYX, INC. | 2010-09-16 | — | — | US | disclosed |
| WO-2008008374-A2 | CCR2 INHIBITORS AND METHODS OF USE THEREOF | CHEMOCENTRYX, INC. (US) | 2008-01-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100234364-A1 | CCR2 INHIBITORS AND METHODS OF USE THEREOF | CCR2, CCR9, CCR1 | HSP90AA1 2051/4885HSP90AB1 1860/4885AURKA 4520/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.