Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 2/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | HSPD1 | P10809 | 2/20 | 0.39 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3101445 | 0.91 | HSP90AA1 (0.41) | CYP3A4AXLBRAFDYRK1ACYP2C9 | |
| SCHEMBL4781338 | 0.87 | SLC40A1 (0.48) | LMNASMN1; SMN2KMT2AMEN1PTPN2 | |
| SCHEMBL4779280 | 0.86 | SLC40A1 (0.51) | AXLBRAFLMNAKMT2AMEN1 | |
| SCHEMBL4780017 | 0.84 | KAT6A (0.39) | BRAFKAT6AKMT2AMEN1PKM | |
| SCHEMBL3098055 | 0.84 | AXL (0.52) | CYP3A4AXLCYP2C9KMT2AMEN1 | |
| SCHEMBL3091703 | 0.84 | CCR9 (0.43) | KMT2AMEN1 | |
| SCHEMBL4781354 | 0.83 | BRAF (0.42) | BRAFKMT2APOLBMEN1HSP90AA1 | |
| SCHEMBL4780645 | 0.83 | PIK3CD (0.43) | POLBKITALDH1A1 | |
| SCHEMBL4775781 | 0.81 | ALDH1A1 (0.46) | LMNAKMT2APOLBMEN1NPC1 | |
| SCHEMBL4781817 | 0.78 | SLC40A1 (0.48) | HSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008008374-A2 | CCR2 INHIBITORS AND METHODS OF USE THEREOF | CHEMOCENTRYX, INC. (US) | 2008-01-17 | — | — | WO | claimed |
| WO-2008008374-A2 | CCR2 INHIBITORS AND METHODS OF USE THEREOF | CHEMOCENTRYX, INC. (US) | 2008-01-17 | — | — | WO | disclosed |