Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.48 |
| ▸ | ACLY | P53396 | 1/20 | 0.43 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.43 |
| ▸ | PIK3C2G | O75747 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 4/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | WDR5 | P61964 | 1/20 | 0.41 |
| ▸ | EDNRB | P24530 | 1/20 | 0.41 |
| ▸ | EDNRA | P25101 | 1/20 | 0.41 |
| ▸ | CCR2 | P41597 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | FBP1 | P09467 | 1/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
| ▸ | CCR1 | P32246 | 1/20 | 0.40 |
| ▸ | CCR4 | P51679 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3101445 | 0.87 | HSP90AA1 (0.41) | PIK3C2BPIK3C2GKDRAURKBHSP90AA1 | |
| SCHEMBL3098833 | 0.86 | SLC40A1 (0.55) | SLC40A1ACLYPGRSCN9AEDNRB | |
| SCHEMBL4781517 | 0.85 | MEN1 (0.41) | ACLYPIK3C2BPIK3C2GSCN9AKDR | |
| SCHEMBL4782048 | 0.84 | PGR (0.54) | SLC40A1PGRSCN9ACCR4 | |
| SCHEMBL4778521 | 0.84 | SLC40A1 (0.51) | SLC40A1ACLYSCN9ACCR2 | |
| SCHEMBL4777634 | 0.81 | SLC40A1 (0.47) | SLC40A1ACLYPGRSCN9AEDNRB | |
| SCHEMBL4781730 | 0.80 | CCR2 (0.53) | SLC40A1ACLYSCN9ACCR2CCR1 | |
| SCHEMBL13146426 | 0.79 | CCR2 (0.52) | SCN9ACCR2CCR1CCR4 | |
| SCHEMBL4781338 | 0.78 | SLC40A1 (0.48) | SLC40A1EDNRBEDNRA | |
| SCHEMBL4780299 | 0.78 | CYP3A4 (0.41) | HSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008008374-A2 | CCR2 INHIBITORS AND METHODS OF USE THEREOF | CHEMOCENTRYX, INC. (US) | 2008-01-17 | — | — | WO | claimed |
| WO-2008008374-A2 | CCR2 INHIBITORS AND METHODS OF USE THEREOF | CHEMOCENTRYX, INC. (US) | 2008-01-17 | — | — | WO | disclosed |