SCHEMBL3101734

SCHEMBL3101734

CC=CC(=O)OCCC[SiH2]C(c1ccccc1)c1ccccc1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 4/20 0.38
AKR1B10 O60218 4/20 0.38
AKR1B1 P15121 4/20 0.38
LMNA P02545 2/20 0.38
MDM4 O15151 1/20 0.38
MAPT P10636 1/20 0.38
MDM2 Q00987 1/20 0.38
ALDH1A1 P00352 2/20 0.37
ALOX5 P09917 1/20 0.36
ATM Q13315 1/20 0.36
NPC1 O15118 2/20 0.35
RAB9A P51151 2/20 0.35
SMN1; SMN2 Q16637 2/20 0.35
MEN1 O00255 1/20 0.35
KMT2A Q03164 1/20 0.35
KDM4E B2RXH2 1/20 0.35
CHRM2 P08172 2/20 0.35
CHRM4 P08173 2/20 0.35
CHRM1 P11229 2/20 0.35
CHRM3 P20309 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6441199 0.87 MAPT (0.40) HCAR2AKR1B10AKR1B1LMNAMDM4
SCHEMBL4661265 0.83 THRB (0.50) HCAR2AKR1B10AKR1B1LMNAALDH1A1
SCHEMBL10526049 0.80 HCAR2 (0.35) HCAR2AKR1B10AKR1B1LMNAMDM4
SCHEMBL3101738 0.77 TDP1 (0.46) LMNAALDH1A1NPC1RAB9ASMN1; SMN2
SCHEMBL3407010 0.75 ATM (0.43) HCAR2MAPTALDH1A1ATMRAB9A
SCHEMBL26095820 0.75 ATM (0.43) HCAR2MAPTALDH1A1ATMRAB9A
SCHEMBL26095033 0.75 ATM (0.43) HCAR2MAPTALDH1A1ATMRAB9A
SCHEMBL1448492 0.75 ATM (0.43) HCAR2MAPTALDH1A1ATMRAB9A
SCHEMBL341121 0.74 ATM (0.42) HCAR2LMNAMAPTALDH1A1ATM
SCHEMBL10526529 0.73 HCAR2 (0.36) HCAR2AKR1B10AKR1B1ALDH1A1ALOX5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 116 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7495052-B2 Method for the production of polymerized nanoparticles and microparticles by ternary agent concentration and temperature alteration induced immiscibility BAUSCH & LOMB INCORPORATED (US) 2009-02-24 US claimed
EP-1444239-B1 HIGH REFRACTIVE INDEX AROMATIC-BASED SILYL MONOMERS BAUSCH & LOMB (US) 2008-12-24 EP claimed
EP-1448571-B1 HIGH REFRACTIVE INDEX AROMATIC-BASED SILOXANE MONOFUNCTIONAL MACROMONOMERS BAUSCH & LOMB (US) 2008-05-21 EP claimed
US-7169874-B2 High refractive index polymeric siloxysilane compositions BAUSCH & LOMB INCORPORATED (US) 2007-01-30 US claimed
WO-2006137855-A2 METHOD FOR THE PRODUCTION OF POLYMERIZED NANOPARTICLES AND MICROPARTICLES BY TERNARY AGENT CONCENTRATION AND TEMPERATURE ALTERATION INDUCED IMMISCIBILITY BAUSCH & LOMB INCORPORATED (US) 2006-12-28 WO claimed
US-20060057222-A1 Method for the production of polymerized nanoparticles and microparticles by ternary agent concentration and temperature alteration induced immiscibility BAUSCH & LOMB INCORPORATED 2006-03-16 US claimed
US-6908978-B2 High refractive index polymeric siloxysilane compositions BAUSCH & LOMB INCORPORATED (US) 2005-06-21 US claimed
US-20050085611-A1 High refractive index aromatic-based siloxane difunctional macromonomers BAUSCH & LOMB MEXICO, S.A. DE C.V. (MX) 2005-04-21 US claimed
EP-1519968-A1 LOW WATER CONTENT HIGH REFRACTIVE INDEX, FLEXIBLE, POLYMERIC COMPOSITIONS BAUSCH & LOMB INCORPORATED (US) 2005-04-06 EP claimed
US-6852793-B2 Low water content, high refractive index, flexible, polymeric compositions BAUSCH & LOMB INCORPORATED (US) 2005-02-08 US claimed
US-20030144451-A1 High refractive index aromatic-based siloxane difunctional macromonomers BAUSCH HEALTH US, LLC 2003-07-31 US claimed
US-20030139557-A1 High refractive index aromatic-based siloxane monofunctional macromonomers PRECISION DERMATOLOGY, INC. 2003-07-24 US claimed
US-20030109661-A1 High refractive index polymeric siloxysilane compositions BAUSCH HEALTH US, LLC 2003-06-12 US claimed
US-20030105255-A1 High refractive index aromatic-based silyl monomers BAUSCH HEALTH, CANADA INC. / SANTE BAUSCH, CANADA INC. (CA) 2003-06-05 US claimed
US-20030100697-A1 High refractive index polymeric siloxysilane compositions SALIX PHARMACEUTICALS, INC. 2003-05-29 US claimed
WO-2003040154-A1 HIGH REFRACTIVE INDEX AROMATIC-BASED SILOXANE DIFUNCTIONAL MACROMONOMERS BAUSCH & LOMB INCORPORATED (US) 2003-05-15 WO claimed
WO-2003040155-A1 HIGH REFRACTIVE INDEX AROMATIC-BASED SILOXANE MONOFUNCTIONAL MACROMONOMERS BAUSCH & LOMB INCORPORATED (US) 2003-05-15 WO claimed
WO-2003040152-A1 HIGH REFRACTIVE INDEX AROMATIC-BASED SILYL MONOMERS BAUSCH & LOMB INCORPORATED (US) 2003-05-15 WO claimed
WO-2003040157-A1 HIGH REFRACTIVE INDEX POLYMERIC SILOXYSILANE COMPOSITIONS BAUSCH & LOMB INCORPORATED (US) 2003-05-15 WO claimed
WO-2003040158-A1 HIGH REFRACTIVE INDEX POLYMERIC SILOXYSILANE COMPOSITIONS BAUSCH & LOMB INCORPORATED (US) 2003-05-15 WO claimed