Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 2/20 | 0.45 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.41 |
| ▸ | MAP3K11 | Q16584 | 3/20 | 0.41 |
| ▸ | FLT3 | P36888 | 2/20 | 0.41 |
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | CHUK | O15111 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | INSR | P06213 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.40 |
| ▸ | FLT1 | P17948 | 2/20 | 0.40 |
| ▸ | FLT4 | P35916 | 2/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | ROS1 | P08922 | 1/20 | 0.40 |
| ▸ | MARK3 | P27448 | 1/20 | 0.40 |
| ▸ | CLK2 | P49760 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31023220 | 0.89 | CHEK1 (0.46) | FAAHCD274MAP3K11FLT3IKBKB | |
| SCHEMBL299467 | 0.87 | CD274 (0.51) | CD274MAP3K11FLT3IKBKBCHUK | |
| SCHEMBL7874310 | 0.81 | FGFR1 (0.49) | FAAHMAP3K11FLT3IKBKBCHUK | |
| SCHEMBL7874293 | 0.77 | MAP3K11 (0.61) | MAP3K11FLT3IKBKBCHUKABL1 | |
| SCHEMBL298617 | 0.74 | MAP3K11 (0.58) | MAP3K11FLT3IKBKBCHUKABL1 | |
| SCHEMBL299250 | 0.73 | CD274 (0.53) | CD274MAP3K11FLT3IKBKBCHUK | |
| SCHEMBL29178532 | 0.72 | FGFR1 (0.50) | MAP3K11FLT3IKBKBCHUKABL1 | |
| SCHEMBL14345090 | 0.69 | ALDH1A1 (0.66) | CYP2D6MEN1ALDH1A1CYP2C9TSHR | |
| SCHEMBL298859 | 0.68 | KDR (0.54) | CD274FLT3FGFR1KDRPIK3CA | |
| SCHEMBL18129777 | 0.68 | CD274 (0.52) | CD274FLT3FGFR1KDRPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240246966-A1 | NEW PYRAZOLO[1,5-a] PYRIMIDINE DERIVATIVES AS SIGMA LIGANDS | ACONDICIONAMIENTO TARRASENSE (ES) | 2024-07-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240246966-A1 | NEW PYRAZOLO[1,5-a] PYRIMIDINE DERIVATIVES AS SIGMA LIGANDS | SIGMAR1, TMEM97, P2RX5 | FAAH 2249/4885CD274 1791/4885MAP3K11 1309/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.