Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | FAAH | O00519 | 3/20 | 0.43 |
| ▸ | MAP3K11 | Q16584 | 3/20 | 0.41 |
| ▸ | FLT3 | P36888 | 2/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | CHUK | O15111 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | INSR | P06213 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 2/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.40 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31023203 | 0.89 | FAAH (0.45) | CHEK1ACHEFAAHMAP3K11FLT3 | |
| SCHEMBL299467 | 0.83 | CD274 (0.51) | CHEK1ACHEMAP3K11FLT3FGFR1 | |
| SCHEMBL7874310 | 0.82 | FGFR1 (0.49) | FAAHMAP3K11FLT3FGFR1KDR | |
| SCHEMBL7874293 | 0.78 | MAP3K11 (0.61) | MAP3K11FLT3FGFR1KDRIKBKB | |
| SCHEMBL298617 | 0.75 | MAP3K11 (0.58) | MAP3K11FLT3FGFR1KDRIKBKB | |
| SCHEMBL29178532 | 0.73 | FGFR1 (0.50) | MAP3K11FLT3FGFR1KDRIKBKB | |
| SCHEMBL20503980 | 0.70 | OPRM1 (0.40) | MAP3K11FLT3FGFR1KDRJAK2 | |
| SCHEMBL299250 | 0.69 | CD274 (0.53) | MAP3K11FLT3FGFR1KDRIKBKB | |
| SCHEMBL20203524 | 0.68 | CHEK1 (0.41) | CHEK1ACHEJAK2SYKCYP2D6 | |
| SCHEMBL18123312 | 0.68 | ALDH1A1 (0.63) | CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240246966-A1 | NEW PYRAZOLO[1,5-a] PYRIMIDINE DERIVATIVES AS SIGMA LIGANDS | ACONDICIONAMIENTO TARRASENSE (ES) | 2024-07-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240246966-A1 | NEW PYRAZOLO[1,5-a] PYRIMIDINE DERIVATIVES AS SIGMA LIGANDS | SIGMAR1, TMEM97, P2RX5 | CHEK1 3525/4885ACHE 2947/4885FAAH 2249/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.