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SCHEMBL31023744

SCHEMBL31023744

CC(C)(C)OC(=O)N1CC2(CC(C(c3ccc4c(c3)COCO4)c3ccc4c(c3)COCO4)C2)C1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GPR183 P32249 1/20 0.43
▸ OXTR P30559 1/20 0.38
▸ AVPR1A P37288 1/20 0.38
▸ NR3C1 P04150 1/20 0.36
▸ MMP13 P45452 1/20 0.36
▸ MAPT P10636 5/20 0.35
▸ NPC1 O15118 1/20 0.35
▸ ALDH1A1 P00352 1/20 0.35
▸ MAPK1 P28482 1/20 0.35
▸ HTT P42858 1/20 0.35
▸ RAB9A P51151 1/20 0.35
▸ L3MBTL1 Q9Y468 1/20 0.35
▸ SCD5 Q86SK9 2/20 0.35
▸ MGLL Q99685 2/20 0.34
▸ KRAS P01116 1/20 0.34
▸ GPR119 Q8TDV5 1/20 0.33
▸ POLB P06746 2/20 0.33
▸ BMP1 P13497 1/20 0.33
▸ ACACB O00763 2/20 0.33
▸ EHMT2 Q96KQ7 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31071489 0.87 GPR183 (0.42) GPR183OXTRAVPR1ANR3C1MMP13
SCHEMBL31023781 0.83 NR1H2 (0.40) GPR183NR3C1MMP13MAPTNPC1
SCHEMBL31023812 0.82 GPR183 (0.51) GPR183ALDH1A1SCD5GPR119ACACB
SCHEMBL31023833 0.81 GPR183 (0.48) GPR183ALDH1A1SCD5GPR119ACACB
SCHEMBL31023775 0.79 GPR183 (0.49) GPR183ALDH1A1SCD5ACACB
SCHEMBL31023904 0.78 GPR183 (0.49) GPR183ALDH1A1SCD5GPR119ACACB
SCHEMBL31071486 0.77 FAAH (0.38) GPR183NR3C1MMP13MAPTNPC1
SCHEMBL31023896 0.77 GPR183 (0.45) GPR183MMP13ALDH1A1SCD5GPR119
SCHEMBL31023944 0.77 SCD5 (0.44) GPR183NR3C1MMP13MAPTNPC1
SCHEMBL31023879 0.77 GPR183 (0.44) GPR183OXTRAVPR1AMMP13SCD5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4665718-A1 SMALL MOLECULES AS MONOACYLGLYCEROL LIPASE (MAGL) INHIBITORS, COMPOSITIONS AND USE THEREOF Apogee Pharmaceuticals, Inc. (CA) 2025-12-24 — — EP disclosed
US-12378231-B2 Small molecules as monoacylglycerol lipase (MAGL) inhibitors, compositions and use thereof APOGEE PHARMACEUTICALS, INC. (CA) 2025-08-05 — — US disclosed
US-20240294514-A1 SMALL MOLECULES AS MONOACYLGLYCEROL LIPASE (MAGL) INHIBITORS, COMPOSITIONS AND USE THEREOF APOGEE PHARMACEUTICALS, INC. (CA) 2024-09-05 — — US disclosed
WO-2024168426-A1 SMALL MOLECULES AS MONOACYLGLYCEROL LIPASE (MAGL) INHIBITORS, COMPOSITIONS AND USE THEREOF APOGEE PHARMACEUTICALS, INC. (CA) 2024-08-22 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12378231-B2 Small molecules as monoacylglycerol lipase (MAGL) inhibitors, compositions and use thereof MGLL, PNLIP, LPL GPR183 2144/4885OXTR 3431/4885AVPR1A 4688/4885
US-20240294514-A1 SMALL MOLECULES AS MONOACYLGLYCEROL LIPASE (MAGL) INHIBITORS, COMPOSITIONS AND USE THEREOF MGLL, PNLIP, LPL GPR183 2144/4885OXTR 3431/4885AVPR1A 4688/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.