⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2327689 | 0.81 | — | — | |
| SCHEMBL8567643 | 0.81 | — | — | |
| Bromide SCHEMBL15688303 | 0.78 | LMNA (0.36) | — | |
| SCHEMBL25259710 | 0.75 | KDM4E (0.32) | — | |
| SCHEMBL6718290 | 0.74 | — | — | |
| SCHEMBL30229716 | 0.74 | — | — | |
| SCHEMBL2493955 | 0.74 | — | — | |
| SCHEMBL2492265 | 0.72 | — | — | |
| SCHEMBL8176802 | 0.71 | GABRA1 (0.30) | — | |
| SCHEMBL856372 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4658640-A1 | PYRIDIN-2(1H)-ONES AND PYRIMIDIN-4(3H)-ONES AS NLRP3 INHIBITORS | Janssen Pharmaceutica NV (BE) | 2025-12-10 | — | — | EP | disclosed |
| WO-2024160693-A1 | PYRIDIN-2(1H)-ONES AND PYRIMIDIN-4(3H)-ONES AS NLRP3 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2024-08-08 | — | — | WO | disclosed |