Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | GSR | P00390 | 1/20 | 0.36 |
| ▸ | LOX | P28300 | 1/20 | 0.35 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29563944 | 0.84 | MBOAT4 (0.44) | LMNAALDH1A1MBOAT4MAP4K4JAK2 | |
| SCHEMBL24612155 | 0.78 | MBOAT4 (0.44) | MBOAT4HTR2AHTR2CKCNH2LOX | |
| SCHEMBL28536047 | 0.78 | MBOAT4 (0.43) | LMNAMBOAT4MAP4K4JAK2LOX | |
| SCHEMBL3129623 | 0.77 | LMNA (0.39) | LMNAALDH1A1 | |
| SCHEMBL1851646 | 0.77 | ADRA2A (0.41) | ALDH1A1FFAR1 | |
| SCHEMBL568140 | 0.76 | LOXL2 (0.47) | MBOAT4HTR2AHTR2CKCNH2LOX | |
| SCHEMBL23530021 | 0.76 | PTGS2 (0.43) | MBOAT4HTR2AHTR2CKCNH2MAP4K4 | |
| SCHEMBL18457325 | 0.76 | PTGDR2 (0.45) | LMNAMBOAT4NAMPTGPR119PTGS1 | |
| SCHEMBL2697225 | 0.75 | KMT2A (0.47) | ALDH1A1MAP4K4JAK2PTGS2ENPP2 | |
| SCHEMBL2653485 | 0.75 | ALDH1A1 (0.64) | LMNAALDH1A1PRMT1GSRENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2324028-A2 | THERAPEUTIC AGENTS 414 | AstraZeneca AB (SE) | 2011-05-25 | — | — | EP | disclosed |
| WO-2010015849-A2 | THERAPEUTIC AGENTS 414 | ASTRAZENECA AB (SE) | 2010-02-11 | — | — | WO | disclosed |