Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | STAT1 | P42224 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | TET3 | O43151 | 1/20 | 0.51 |
| ▸ | FBXL19 | Q6PCT2 | 1/20 | 0.51 |
| ▸ | CXXC5 | Q7LFL8 | 1/20 | 0.51 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.51 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.51 |
| ▸ | CXXC4 | Q9H2H0 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3102395 | 0.99 | SMN1; SMN2 (0.52) | SMN1; SMN2ALDH1A1HPGDLMNANPC1 | |
| SCHEMBL3097606 | 0.89 | TSHR (0.58) | SMN1; SMN2ALDH1A1HPGDTP53MAPT | |
| SCHEMBL3110127 | 0.88 | POLB (0.52) | SMN1; SMN2ALDH1A1HPGDLMNAHSD17B10 | |
| SCHEMBL3099738 | 0.86 | KDM4E (0.53) | SMN1; SMN2ALDH1A1LMNATSHRHSD17B10 | |
| SCHEMBL3101546 | 0.83 | ALDH1A1 (0.59) | ALDH1A1HPGDLMNATSHRKMT2A | |
| SCHEMBL3101764 | 0.82 | MAPK1 (0.62) | SMN1; SMN2ALDH1A1HPGDLMNATP53 | |
| SCHEMBL3229607 | 0.82 | ALDH1A1 (0.57) | SMN1; SMN2ALDH1A1HPGDLMNATP53 | |
| SCHEMBL3098740 | 0.81 | KMT2A (0.48) | ALDH1A1HPGDLMNATP53TSHR | |
| SCHEMBL7901820 | 0.81 | TSHR (0.46) | SMN1; SMN2ALDH1A1ALOX15TSHRHSD17B10 | |
| SCHEMBL14080354 | 0.81 | KMT2A (0.50) | SMN1; SMN2ALDH1A1HPGDLMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8324250-B2 | Piperidine derivatives as NK3 receptor antagonists | HOFFMANN-LA ROCHE INC. (US) | 2012-12-04 | — | — | US | disclosed |
| US-20100256126-A1 | PIPERIDINE DERIVATIVES AS NK3 RECEPTOR ANTAGONISTS | HOFFMANN-LA ROCHE, INC. | 2010-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100256126-A1 | PIPERIDINE DERIVATIVES AS NK3 RECEPTOR ANTAGONISTS | HTR3A, OPRL1, OPRK1 | SMN1; SMN2 1960/4885ALDH1A1 480/4885HPGD 1256/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.