Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 2/20 | 0.60 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | PGR | P06401 | 1/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | NAMPT | P43490 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.49 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.49 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1223807 | 0.87 | RAB9A (0.67) | TP53MAPTSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL31043761 | 0.86 | AR (0.55) | ARTP53MAPTSMN1; SMN2RAB9A | |
| SCHEMBL11813314 | 0.84 | TP53 (0.68) | TP53MAPTSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL6743384 | 0.83 | MAPT (0.62) | TP53MAPTSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL23747417 | 0.82 | NPC1 (0.71) | SMN1; SMN2RAB9ANPC1NAMPTCA2 | |
| SCHEMBL6401410 | 0.81 | CA1 (0.54) | ARMAPTSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL3034797 | 0.79 | MIF (0.60) | TP53MAPTSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL28221690 | 0.78 | HDAC8 (0.62) | ARTP53MAPTSMN1; SMN2RAB9A | |
| SCHEMBL6466509 | 0.77 | MET (0.61) | MAPTSMN1; SMN2RAB9ANPC1ALDH1A1 | |
| SCHEMBL29031236 | 0.77 | PGR (0.68) | ARMAPTSMN1; SMN2PGRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240279215-A1 | NAMPT MODULATORS | CYTOKINETICS, INCORPORATED | 2024-08-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240279215-A1 | NAMPT MODULATORS | NAMPT, SIRT1, NNT | AR 924/4885TP53 4825/4885MAPT 766/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.