Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 10/20 | 0.50 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.42 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.42 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.42 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.42 |
| ▸ | CACNG3 | O60359 | 1/20 | 0.42 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.42 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.42 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.42 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.42 |
| ▸ | CACNG7 | P62955 | 1/20 | 0.42 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.42 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.42 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.42 |
| ▸ | CACNG1 | Q06432 | 1/20 | 0.42 |
| ▸ | CACNB2 | Q08289 | 1/20 | 0.42 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.42 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.42 |
| ▸ | CACNA1E | Q15878 | 1/20 | 0.42 |
| ▸ | CACNA2D4 | Q7Z3S7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30102016 | 0.88 | GPR119 (0.64) | GPR119HRH3 | |
| SCHEMBL1372747 | 0.88 | GPR119 (0.64) | GPR119HRH3 | |
| SCHEMBL24214214 | 0.88 | GPR119 (0.48) | GPR119GABRA5CACNB4CACNA1ACACNA1G | |
| SCHEMBL31401120 | 0.84 | DGAT1 (0.57) | GPR119CACNB4CACNA1ACACNA1GCACNG3 | |
| SCHEMBL15525341 | 0.84 | DGAT1 (0.57) | GPR119CACNB4CACNA1ACACNA1GCACNG3 | |
| SCHEMBL3398165 | 0.84 | GPR119 (0.51) | GPR119CACNB4CACNA1ACACNA1GCACNG3 | |
| SCHEMBL28418487 | 0.84 | FAAH (0.54) | GPR119CACNB4CACNA1ACACNA1GCACNG3 | |
| SCHEMBL14861989 | 0.84 | GPR119 (0.51) | GPR119CACNB4CACNA1ACACNA1GCACNG3 | |
| SCHEMBL31312638 | 0.82 | LIPE (0.51) | GPR119HRH3 | |
| SCHEMBL13216270 | 0.81 | GPR119 (0.48) | GPR119CACNB4CACNA1ACACNA1GCACNG3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111285873-B | RET inhibitor, pharmaceutical composition thereof and application thereof | 广东东阳光药业股份有限公司 | 2024-10-15 | — | — | CN | disclosed |
| CN-111285874-B | RET inhibitor, pharmaceutical composition thereof and application thereof | 广东东阳光药业股份有限公司 | 2024-08-09 | — | — | CN | disclosed |