Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KRAS | P01116 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 3/20 | 0.38 |
| ▸ | QPCT | Q16769 | 3/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31049359 | 0.82 | HTT (0.37) | SMN1; SMN2HTTMAPTLMNATDP1 | |
| SCHEMBL31049365 | 0.81 | HTT (0.36) | SMN1; SMN2HTTMAPTLMNATDP1 | |
| SCHEMBL10095336 | 0.78 | SMN1; SMN2 (0.57) | SMN1; SMN2GAAHTTMAPTKRAS | |
| SCHEMBL981509 | 0.75 | SMN1; SMN2 (0.60) | SMN1; SMN2GAAKRASNPSR1LMNA | |
| SCHEMBL31049266 | 0.72 | L3MBTL1 (0.33) | SMN1; SMN2HTTMAPTLMNATDP1 | |
| SCHEMBL22153072 | 0.69 | HTT (0.43) | SMN1; SMN2GAAHTTMAPTKRAS | |
| SCHEMBL22152181 | 0.68 | KDM1A (0.44) | SMN1; SMN2GAAHTTMAPTKRAS | |
| SCHEMBL29992283 | 0.68 | XDH (0.55) | SMN1; SMN2GAAMAPTKRASNPSR1 | |
| SCHEMBL2417482 | 0.67 | IMPDH2 (0.59) | SMN1; SMN2GAAKRASNPSR1GSK3B | |
| SCHEMBL31049343 | 0.67 | GRIN2B (0.32) | NPSR1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118359627-A | MTA synergistic PRMT5 inhibitor compounds having a tetracyclic fused ring structure | 烨辉医药科技(上海)有限公司 | 2024-07-19 | — | — | CN | disclosed |