Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | XDH | P47989 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31049264 | 0.81 | SMN1; SMN2 (0.45) | HTTMAPTLMNAL3MBTL1SMN1; SMN2 | |
| SCHEMBL31049359 | 0.79 | HTT (0.37) | HTTMAPTLMNAL3MBTL1SMN1; SMN2 | |
| SCHEMBL31049402 | 0.74 | KDM4E (0.34) | MAPTL3MBTL1TDP1 | |
| SCHEMBL31049266 | 0.68 | L3MBTL1 (0.33) | HTTMAPTLMNAL3MBTL1SMN1; SMN2 | |
| SCHEMBL1077430 | 0.64 | MAPT (0.64) | HTTMAPTLMNAL3MBTL1SMN1; SMN2 | |
| SCHEMBL31049261 | 0.62 | KDM4E (0.37) | HTTMAPTL3MBTL1SMN1; SMN2TSHR | |
| SCHEMBL27957397 | 0.62 | MAPT (0.66) | HTTMAPTLMNAL3MBTL1SMN1; SMN2 | |
| SCHEMBL10095336 | 0.61 | SMN1; SMN2 (0.57) | HTTMAPTL3MBTL1SMN1; SMN2XDH | |
| SCHEMBL7100687 | 0.60 | DAO (0.43) | HTTMAPTL3MBTL1TSHR | |
| SCHEMBL18883079 | 0.58 | NOTUM (0.53) | MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118359627-A | MTA synergistic PRMT5 inhibitor compounds having a tetracyclic fused ring structure | 烨辉医药科技(上海)有限公司 | 2024-07-19 | — | — | CN | disclosed |