Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 3/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.31 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.31 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.31 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | REN | P00797 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31049264 | 0.72 | SMN1; SMN2 (0.45) | L3MBTL1MAPTHTTGSK3BLMNA | |
| SCHEMBL16263096 | 0.70 | XDH (0.44) | L3MBTL1MAPTMEN1ALDH1A1KMT2A | |
| SCHEMBL31049261 | 0.68 | KDM4E (0.37) | L3MBTL1MAPTHTTGSK3BGRIN2B | |
| SCHEMBL31049359 | 0.68 | HTT (0.37) | L3MBTL1MAPTHTTLMNASMN1; SMN2 | |
| SCHEMBL31049365 | 0.68 | HTT (0.36) | L3MBTL1MAPTHTTLMNASMN1; SMN2 | |
| SCHEMBL7854517 | 0.65 | ELANE (0.60) | L3MBTL1MAPTHTTGSK3BLMNA | |
| SCHEMBL31049503 | 0.64 | AR (0.32) | — | |
| SCHEMBL7100687 | 0.63 | DAO (0.43) | L3MBTL1MAPTHTTALDH1A1KCNA3 | |
| SCHEMBL31049367 | 0.61 | GRIN2B (0.36) | L3MBTL1MAPTHTTGRIN2BMEN1 | |
| SCHEMBL31049343 | 0.61 | GRIN2B (0.32) | L3MBTL1GRIN2BALDH1A1KCNA3KCNA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118359627-A | MTA synergistic PRMT5 inhibitor compounds having a tetracyclic fused ring structure | 烨辉医药科技(上海)有限公司 | 2024-07-19 | — | — | CN | disclosed |