Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 9/20 | 0.43 |
| ▸ | PGR | P06401 | 8/20 | 0.43 |
| ▸ | NR3C2 | P08235 | 8/20 | 0.43 |
| ▸ | AR | P10275 | 8/20 | 0.43 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 4/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.36 |
| ▸ | CCNK | O75909 | 2/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.36 |
| ▸ | CDK2 | P24941 | 2/20 | 0.36 |
| ▸ | CDK9 | P50750 | 2/20 | 0.36 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.36 |
| ▸ | CDK7 | P50613 | 2/20 | 0.36 |
| ▸ | CCNH | P51946 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29364536 | 0.79 | ADRB3 (0.37) | NR3C1PGRNR3C2ARADRB3 | |
| SCHEMBL31049406 | 0.73 | GPR84 (0.64) | GPR84SLC6A4MPO | |
| SCHEMBL31049280 | 0.72 | HTR2A (0.56) | ARGPR84 | |
| SCHEMBL6091351 | 0.72 | NR3C1 (0.48) | NR3C1PGRNR3C2ARADRB3 | |
| SCHEMBL5729189 | 0.70 | BRPF1 (0.56) | NR3C1PGRNR3C2AR | |
| SCHEMBL13165739 | 0.70 | CDK2 (0.46) | CDK2 | |
| SCHEMBL5730144 | 0.69 | NR4A2 (0.49) | NR3C1PGRNR3C2ARSLC6A4 | |
| SCHEMBL31049376 | 0.69 | GPR84 (0.39) | ARGPR84CCNT1CCNKCCNE1 | |
| SCHEMBL31049262 | 0.68 | DYRK1A (0.55) | ARGPR84SLC6A4MPO | |
| SCHEMBL28002632 | 0.68 | IMPDH2 (0.50) | GPR84SLC6A4MPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118359627-A | MTA synergistic PRMT5 inhibitor compounds having a tetracyclic fused ring structure | 烨辉医药科技(上海)有限公司 | 2024-07-19 | — | — | CN | disclosed |