SCHEMBL3105572

SCHEMBL3105572

CCCOc1cc(I)ccc1Cl

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CSNK2A1 P68400 2/20 0.47
ALDH1A1 P00352 3/20 0.44
MAPT P10636 3/20 0.44
MEN1 O00255 2/20 0.44
USP2 O75604 2/20 0.44
POLB P06746 2/20 0.44
KMT2A Q03164 2/20 0.44
CYP2C9 P11712 2/20 0.44
CYP2C19 P33261 2/20 0.44
L3MBTL1 Q9Y468 2/20 0.44
HPGD P15428 1/20 0.44
ALOX12 P18054 1/20 0.44
MAPK1 P28482 1/20 0.44
NPSR1 Q6W5P4 1/20 0.44
FABP4 P15090 1/20 0.42
KDM4E B2RXH2 1/20 0.40
TP53 P04637 1/20 0.40
GAA P10253 1/20 0.40
CASP1 P29466 1/20 0.40
HTT P42858 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28089646 0.84 L3MBTL1 (0.50) ALDH1A1MAPTMEN1USP2POLB
SCHEMBL15087903 0.82 L3MBTL1 (0.45) ALDH1A1MAPTMEN1USP2POLB
SCHEMBL26667637 0.81 ALDH1A1 (0.54) CSNK2A1ALDH1A1MAPTMEN1USP2
SCHEMBL3324595 0.80 ALDH1A1 (0.50) ALDH1A1MAPTMEN1USP2POLB
SCHEMBL15086545 0.79 TSHR (0.41) CSNK2A1ALDH1A1MAPTMEN1USP2
SCHEMBL3783768 0.79 CSNK2A1 (0.49) CSNK2A1ALDH1A1MAPTMEN1USP2
SCHEMBL13921776 0.79 MAPT (0.67) CSNK2A1ALDH1A1MAPTMEN1USP2
SCHEMBL19440160 0.78 CSNK2A1 (0.47) CSNK2A1ALDH1A1MAPTMEN1USP2
SCHEMBL3464649 0.78 HPGD (0.51) CSNK2A1ALDH1A1MAPTMEN1USP2
SCHEMBL13841184 0.78 ADRA1D (0.49) CSNK2A1ALDH1A1MAPTMEN1USP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2148878-A1 NOVEL HETEROAROMATIC COMPOUNDS AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE Merck Frosst Canada Ltd. (CA) 2010-02-03 EP disclosed
WO-2008128335-A1 NOVEL HETEROAROMATIC COMPOUNDS AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE MERCK FROSST CANADA LTD. (CA) 2008-10-30 WO disclosed