Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SNCA | P37840 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | ACHE | P22303 | 3/20 | 0.42 |
| ▸ | ATP4A | P20648 | 3/20 | 0.41 |
| ▸ | ATP4B | P51164 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31063750 | 0.86 | SMN1; SMN2 (0.57) | SNCAMAPTATP4AATP4BSMN1; SMN2 | |
| SCHEMBL31063692 | 0.85 | SNCA (0.47) | SNCAMAPTATP4AATP4BSMN1; SMN2 | |
| SCHEMBL31063760 | 0.81 | SNCA (0.46) | SNCAMAPTACHEATP4AATP4B | |
| SCHEMBL31063734 | 0.80 | ATP4A (0.60) | SNCAMAPTATP4AATP4BSMN1; SMN2 | |
| SCHEMBL31063740 | 0.79 | ATP4A (0.58) | SNCAMAPTATP4AATP4BSMN1; SMN2 | |
| SCHEMBL31063720 | 0.76 | INSR (0.49) | SNCAMAPTACHEATP4AATP4B | |
| SCHEMBL31063762 | 0.76 | ATP4A (0.49) | SNCAMAPTACHEATP4AATP4B | |
| SCHEMBL31063753 | 0.73 | RAB9A (0.53) | SNCAMAPTATP4AATP4BSMN1; SMN2 | |
| SCHEMBL31063730 | 0.71 | NPC1 (0.57) | SNCAMAPTATP4AATP4BSMN1; SMN2 | |
| SCHEMBL31063756 | 0.71 | MAPT (0.55) | SNCAMAPTATP4AATP4BSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024200263-A1 | 2-STYRYLBENZOTHIAZOLE DERIVATIVES AS α-SYNUCLEIN BINDING COMPOUNDS | EBERHARD KARLS UNIVERSITAET TUEBINGEN MEDIZINISCHE FAKULTAET (DE) | 2024-10-03 | — | — | WO | disclosed |
| EP-4438597-A1 | 2-STYRYLBENZOTHIAZOLE DERIVATIVES AS A-SYNUCLEIN BINDING COMPOUNDS | Eberhard Karls Universität Tübingen Medizinische Fakultät (DE) | 2024-10-02 | — | — | EP | disclosed |