Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | KLKB1 | P03952 | 6/20 | 0.35 |
| ▸ | F11 | P03951 | 5/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
| ▸ | KLK1 | P06870 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31075246 | 0.85 | F11 (0.40) | KLKB1F11F2RIPK1ACACB | |
| SCHEMBL31075273 | 0.76 | L3MBTL1 (0.46) | ALDH1A1POLBKLKB1RIPK1LMNA | |
| SCHEMBL1414358 | 0.73 | KLKB1 (0.49) | KLKB1RIPK1KLK1 | |
| SCHEMBL31075313 | 0.73 | ALDH1A1 (0.39) | ALDH1A1POLBLMNACASP1ACACB | |
| SCHEMBL23070226 | 0.72 | TSHR (0.43) | KLKB1RIPK1KLK1SMN1; SMN2 | |
| SCHEMBL18366908 | 0.71 | LMNA (0.45) | ALDH1A1POLBKLKB1LMNAKLK1 | |
| SCHEMBL28472523 | 0.71 | HDAC1 (0.41) | POLBKLKB1RIPK1KLK1 | |
| SCHEMBL28279024 | 0.70 | KLKB1 (0.46) | ALDH1A1POLBKLKB1F11F2 | |
| SCHEMBL16246799 | 0.70 | KLKB1 (0.56) | KLKB1F11F2LMNACASP1 | |
| SCHEMBL26969961 | 0.70 | SCD (0.49) | ALDH1A1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4665330-A1 | PLASMA KALLIKREIN INHIBITORS | Merck Sharp & Dohme LLC (US) | 2025-12-24 | — | — | EP | disclosed |
| WO-2024173196-A1 | PLASMA KALLIKREIN INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2024-08-22 | — | — | WO | disclosed |