Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | REN | P00797 | 10/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.37 |
| ▸ | FDPS | P14324 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3136166 | 0.91 | FDPS (0.38) | ALDH1A1MAPTHPGDLMNASMN1; SMN2 | |
| SCHEMBL662039 | 0.84 | FDPS (0.44) | ALDH1A1MAPTHPGDLMNASMN1; SMN2 | |
| SCHEMBL13131319 | 0.83 | ALDH1A1 (0.54) | ALDH1A1MAPTHPGDLMNASMN1; SMN2 | |
| SCHEMBL21300649 | 0.82 | CYP1A2 (0.42) | ALDH1A1MAPTHPGDLMNASMN1; SMN2 | |
| SCHEMBL28054403 | 0.80 | FDPS (0.35) | ALDH1A1MAPTHPGDLMNASMN1; SMN2 | |
| SCHEMBL662558 | 0.80 | PTGS2 (0.42) | CYP3A4CNR1CNR2 | |
| SCHEMBL13411260 | 0.79 | CYP1A1 (0.45) | ALDH1A1MAPTHPGDFDPSEGFR | |
| SCHEMBL6002467 | 0.79 | ALDH1A1 (0.46) | ALDH1A1MAPTHPGDLMNASMN1; SMN2 | |
| SCHEMBL1069742 | 0.78 | ALDH1A1 (0.35) | ALDH1A1MAPTHPGDLMNASMN1; SMN2 | |
| SCHEMBL663232 | 0.78 | PREP (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100249163-A1 | RENIN INHIBITORS | MERCK CANADA INC. (CA) | 2010-09-30 | — | — | US | disclosed |
| EP-2229363-A1 | RENIN INHIBITORS | Merck Frosst Canada Ltd. (CA) | 2010-09-22 | — | — | EP | disclosed |
| WO-2009070869-A1 | RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2009-06-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249163-A1 | RENIN INHIBITORS | REN, ACE, AGTR1 | ALDH1A1 1125/4885MAPT 4060/4885HPGD 751/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.